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Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
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Right Ventricular Pacing and Cardiac Resynchronization Devices.

Tharian S Cherian1, Gaurav A Upadhyay2

  • 1Section of Cardiology, The University of Chicago Medicine, Pritzker School of Medicine, 5841 South Maryland Avenue, Chicago, IL 60637, USA.

Cardiac Electrophysiology Clinics
|February 12, 2018
PubMed
Summary
This summary is machine-generated.

Long-term right ventricular pacing can cause heart problems like pacing-induced cardiomyopathy (PICM). Cardiac resynchronization therapy (CRT) may help prevent and treat this condition in high-risk patients.

Keywords:
CRTPacemaker-induced cardiomyopathyRight ventricular pacing

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Area of Science:

  • Cardiology
  • Electrophysiology
  • Heart Failure

Background:

  • Long-term right ventricular pacing can lead to electrical and mechanical dyssynchrony.
  • A subset of patients develop pacing-induced cardiomyopathy (PICM) due to this dyssynchrony.
  • High pacing burden and reduced left ventricular (LV) function increase PICM risk.

Purpose of the Study:

  • To review predictors of pacing-induced cardiomyopathy (PICM).
  • To highlight the role of cardiac resynchronization therapy (CRT) in PICM prevention and treatment.
  • To identify high-risk patients for PICM development.

Main Methods:

  • Literature review of studies on right ventricular pacing and cardiomyopathy.
  • Analysis of predictors for pacing-induced cardiomyopathy.
  • Evaluation of cardiac resynchronization therapy's efficacy in PICM.

Main Results:

  • Pacing burden and baseline LV function are key predictors of PICM.
  • Cardiac resynchronization therapy (CRT) is effective in treating existing PICM.
  • CRT may offer a preventative strategy for high-risk individuals.

Conclusions:

  • Identifying patients at risk for PICM is crucial.
  • Cardiac resynchronization therapy (CRT) plays a significant role in managing and potentially preventing pacing-induced cardiomyopathy.
  • Further research should focus on optimizing CRT strategies for high-risk populations.