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Hyperprolactinemia and 5-alpha-reductase activity.

I Noci, C Tantini, E Nardi

    Acta Europaea Fertilitatis
    |March 1, 1986
    PubMed
    Summary
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    Hyperprolactinemia inhibits 5-alpha-reductase activity, affecting testosterone and dihydro-testosterone levels. This enzyme block is rapidly reversible, with 5-alpha-reductase reactivating within 48-72 hours after prolactin normalizes.

    Area of Science:

    • Endocrinology
    • Reproductive Biology
    • Enzymology

    Background:

    • Hyperprolactinemia is known to inhibit 5-alpha-reductase activity.
    • The time course for 5-alpha-reductase reactivation after prolactin normalization remains uncharacterized.

    Purpose of the Study:

    • To investigate the reversibility of 5-alpha-reductase inhibition by hyperprolactinemia.
    • To determine the time required for 5-alpha-reductase to reactivate after prolactin levels return to normal.

    Main Methods:

    • Five healthy men received HCG (human chorionic gonadotropin) under basal conditions and after sulpiride-induced hyperprolactinemia.
    • Plasma levels of prolactin, testosterone, dihydro-testosterone, 17-beta-estradiol, and dehydroepiandrosterone sulfate were monitored via RIA (radioimmunoassay).

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    Main Results:

    • Hyperprolactinemia significantly decreased dihydro-testosterone (58%) and testosterone (39%), while increasing dehydroepiandrosterone sulfate (43%).
    • 5-alpha-reductase activity recovered within 48-72 hours post-hyperprolactinemia, indicated by normalized dihydro-testosterone response to HCG.

    Conclusions:

    • Hyperprolactinemia inhibits 5-alpha-reductase, impacting androgen metabolism.
    • The inhibitory effect of hyperprolactinemia on 5-alpha-reductase is rapidly reversible upon prolactin normalization.