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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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Adult Stem Cells01:33

Adult Stem Cells

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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Embryonic Stem Cells00:58

Embryonic Stem Cells

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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Embryonic Stem Cells00:57

Embryonic Stem Cells

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
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Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Urinary Bladder01:23

Urinary Bladder

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The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
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Transplantation of Induced Pluripotent Stem Cell-derived Mesoangioblast-like Myogenic Progenitors in Mouse Models of Muscle Regeneration
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Bladder regeneration through stem cell therapy.

Jakub Smolar1, Maya Horst2, Tulio Sulser3

  • 1a Department of Urology , University Hospital Zurich , Schlieren , Switzerland.

Expert Opinion on Biological Therapy
|February 14, 2018
PubMed
Summary
This summary is machine-generated.

Stem cells show promise for bladder bioengineering, offering an alternative to intestinal tissue repair. Optimizing the microenvironment is key for regenerating functional bladder tissue and improving patient outcomes.

Keywords:
Bladdermicroenvironmentregenerative medicinestem cellstissue engineering

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Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Urology

Background:

  • Impaired bladder function leads to significant lifelong morbidity.
  • Current bladder repair using intestinal tissue has severe long-term complications.
  • There is a critical need for alternative bladder tissue sources.

Purpose of the Study:

  • To review recent advancements in stem cell applications for bladder bioengineering.
  • To explore the role of the microenvironment in stem cell differentiation and tissue regeneration.
  • To discuss strategies for developing functional bladder tissue.

Main Methods:

  • Review of current literature on stem cell-based bladder bioengineering.
  • Analysis of the impact of microenvironmental factors on stem cell behavior.
  • Discussion of scaffold design and cellular interactions for tissue regeneration.

Main Results:

  • Stem cells are a promising source for bladder tissue regeneration.
  • The microenvironment critically influences stem cell differentiation and tissue development.
  • Multi-layered scaffolds with specific microenvironments are essential for functional bladder bioengineering.

Conclusions:

  • Stem cell-based bladder bioengineering offers a potential solution to current therapeutic limitations.
  • Understanding and manipulating the microenvironment is crucial for successful bladder regeneration.
  • In situ stem cell activation and microenvironment repair may provide superior long-term solutions.