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Updated: Feb 14, 2026

Recombineering Homologous Recombination Constructs in Drosophila
Published on: July 13, 2013
An unusual alkylidyne homologation
Yong-Shen Han1, Anthony F Hill, Richard Y Kong
1Research School of Chemistry, Australian National University, Canberra, Australian Capital Territory ACT 2601, Australia. a.hill@anu.edu.au.
Abstract:
The reaction of [W([triple bond, length as m-dash]CH)Br(CO)2(dcpe)] (dcpe = 1,2-bis(dicyclohexylphosphino)ethane) with tBuLi and SiCl4 affords the trichlorosilyl ligated neopentylidyne complex [W([triple bond, length as m-dash]CtBu)(SiCl3)(CO)2(dcpe)]. This slowly reacts with H2O to afford [W([triple bond, length as m-dash]CCH2tBu)Cl3(dcpe)] and ultimately H2C[double bond, length as m-dash]CHtBu via an unprecedented alkylidyne homologation in which coordinated CO is the source of the additional carbon atom with potential relevance to the Fischer-Tropsch process.
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