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Updated: Feb 14, 2026
12:30
A Comprehensive Protocol for Manual Segmentation of the Medial Temporal Lobe Structures
Published on: July 2, 2014
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Dataset of human medial temporal lobe single neuron activity during declarative memory encoding and recognition
Mailys C M Faraut1, April A Carlson1, Shannon Sullivan1
1Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Scientific Data
|February 14, 2018
Summary
This study provides a large dataset of human amygdala and hippocampus neuron recordings during a memory task. The data will aid research into the neural basis of declarative memory.
Area of Science:
- Neuroscience
- Cognitive Neuroscience
- Human Electrophysiology
Background:
- The human amygdala and hippocampus are crucial for memory formation.
- Single-neuron recordings in humans are rare but vital for understanding memory mechanisms.
Purpose of the Study:
- To present a comprehensive dataset of single-neuron recordings from the human amygdala and hippocampus.
- To facilitate research into the neural mechanisms of declarative memory.
Main Methods:
- Recorded 1,576 single neurons from 42 patients undergoing epilepsy monitoring.
- Utilized a recognition memory task with visual stimuli and confidence ratings.
- Collected spike times, waveforms, behavior, electrode locations, demographics, and stimuli.
Main Results:
- Provided technical validation including spike sorting quality and cell tuning analysis.
- Included analysis code to reproduce prior findings on a smaller dataset.
- Established a large-scale dataset for investigating memory-selective cells.
Conclusions:
- The dataset offers a valuable resource for studying declarative memory.
- Enables in-depth analysis of human single-neuron activity during memory tasks.
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