Silver Nanoparticles Modified with Sodium Triphosphate: Antibacterial Activity, Hemocompatibility and Cytotoxicity
Chuhan Cheng1, Cheng Liu2, Bing Han3
1Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Jiangsu Key Laboratory of 3D Printing Equipment and Manufacturing, National and Local Joint Engineering Research Center of Biomedical Functional Materials, Jiangsu Engineering Research Center for Biomedical Function Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210097, China.
Abstract:
In this study, we report silver nanoparticles (Ag NPs) modified with sodium triphosphate (STTP) (Ag-STPP NPs) prepared by a simple surface modification and chemical reduction method. It was confirmed by 31P NMR spectroscopy that STPP was successfully introduced to the surface of Ag NPs. It was revealed by conductivity change measurements, bacterial growth kinetics and antibacterial efficiency tests that Ag-STPP NPs still retained the strong antibacterial ability. It was demonstrated by hemolysis assays, red blood cell morphology measurements, plasma recalcification time and in vitro clotting times that Ag-STPP NPs had improved hemocompatibility. It was also implied by cell viability measurements that Ag-STPP NPs possessed low cytotoxicity and high cytocompatibility. These findings, combined with the low-cost and ease of synthesis, make Ag-STPP NPs a promising candidate for biomedical applications.
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