Related Experiment Video

Updated: Feb 14, 2026

Author Spotlight: Optimizing EAS with Long Electrodes for Enhanced Cochlear Coverage and Hearing Preservation
03:49

Author Spotlight: Optimizing EAS with Long Electrodes for Enhanced Cochlear Coverage and Hearing Preservation

Published on: October 11, 2024

1.2K

Analysis of risk factors associated with unilateral hearing loss in children who initially passed newborn hearing

Eric N Appelbaum1, Jessica B Howell1, Derek Chapman2

  • 1Department of Otolaryngology-HNS, Virginia Commonwealth University, 401 North 11th Street, PO Box 980146, Richmond, VA, 23298, United States.

International Journal of Pediatric Otorhinolaryngology
|February 16, 2018
PubMed

Insights

Neonatal indicators and craniofacial anomalies are key risk factors for unilateral hearing loss (UHL) in infants who pass initial newborn hearing screening. Early identification of these factors is crucial for timely intervention.

Area of Science:

  • Pediatric audiology
  • Neonatal screening
  • Genetics and hearing loss

Background:

  • Newborn hearing screening aims to identify infants with hearing loss early.
  • The Joint Committee on Infant Hearing (JCIH) established risk factors to guide follow-up.
  • Some infants passing initial screening may develop hearing loss later.

Purpose of the Study:

  • To analyze the 2007 Joint Committee on Infant Hearing (JCIH) risk factors in children with confirmed unilateral hearing loss (UHL).
  • To identify infants who initially passed newborn hearing screening but later developed UHL.

Main Methods:

  • Retrospective record review of 16,108 infants from Virginia (2010-2012).
  • Infants included had passed universal newborn hearing screening (UNHS) and possessed one or more JCIH risk factors.
  • Study data was deemed exempt by relevant Institutional Review Boards.

Main Results:

  • 4.9% of infants passed UNHS but had JCIH risk factors.
  • 0.7% of this group were identified with confirmed hearing loss, including 0.2% with UHL (48 babies).
  • Common risk factors for UHL included neonatal indicators, craniofacial anomalies, family history, and stigmata of syndrome.

Conclusions:

  • Neonatal indicators and craniofacial anomalies were most prevalent in children with confirmed UHL post-screening.
  • Craniofacial abnormalities were relatively more common in UHL cases compared to all hearing loss categories.
  • Further research into the etiology and specific risk factor associations for hearing loss is recommended.
Abstract

Keywords:
Congenital anomaliesPediatric hearing lossPediatric otologyUnilateral hearing loss

More Related Videos

Behavioral Assessment of Hearing in 2 to 4 Year-old Children: A Two-interval, Observer-based Procedure Using Conditioned Play-based Responses14:05

Behavioral Assessment of Hearing in 2 to 4 Year-old Children: A Two-interval, Observer-based Procedure Using Conditioned Play-based Responses

Published on: January 23, 2017

29.8K
Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss09:44

Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss

Published on: January 25, 2016

19.8K

Related Concept Videos

Hearing01:31

Hearing

When we hear a sound, our nervous system is detecting sound waves—pressure waves of mechanical energy traveling through a medium. The frequency of the wave is perceived as pitch, while the amplitude is perceived as loudness.
57.6K
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.9K
Factors Influencing Bioavailability: First-Pass Elimination01:23

Factors Influencing Bioavailability: First-Pass Elimination

When a drug is taken orally, it undergoes a journey starting from the gastrointestinal (GI) tract, passing through the portal vein, reaching the liver, and finally entering the systemic circulation. This process involves the absorption of the drug across the GI tract. The liver is the primary site for metabolizing the drug, with some metabolism also occurring in the gut wall. This journey significantly reduces the quantity of the drug that reaches the systemic circulation, a phenomenon known as...
8.2K
Drug Toxicity: Risk factors01:24

Drug Toxicity: Risk factors

Adverse Drug Reactions (ADRs) are potential complications that arise during pharmacotherapy, influenced by multiple risk factors. Age plays a significant role; both neonates and the elderly are at heightened risk due to their respective immature and diminished metabolic and elimination processes. Gender also impacts ADRs, with females experiencing a 1.5 to 1.7-fold greater risk than males, which may be linked to pharmacokinetic, pharmacodynamic, and hormonal differences. Notably, neonates, the...
18
First Pass Effect01:12

First Pass Effect

Presystemic elimination, or the first-pass effect, is the metabolism of drugs that reduces their effective concentration at the site of action. Apart from the first-pass effect, the systemic bioavailability of the drug is also reduced by other factors, including incomplete absorption or chemical degradation of drugs.
Depending on the route of administration, drugs can be metabolized in the liver, intestine, lungs, and vasculature. Orally administered drugs are first absorbed through the...
9.7K
Initiation of Translation02:33

Initiation of Translation

Initiating translation is complex because it involves multiple molecules. Initiator tRNA, ribosomal subunits, and eukaryotic initiation factors (eIFs) are all required to assemble on the initiation codon of mRNA. This process consists of several steps that are mediated by different eIFs.
First, the initiator tRNA must be selected from the pool of elongator tRNAs by eukaryotic initiation factor 2 (eIF2). The initiator tRNA (Met-tRNAi) has conserved sequence elements including modified bases at...
39.3K