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Updated: Feb 14, 2026

A Millimeter Scale Flexural Testing System for Measuring the Mechanical Properties of Marine Sponge Spicules
Published on: October 11, 2017
Spongian diterpenes from Chinese marine sponge Spongia officinalis
Guan-Ying Han1, Dong-Yu Sun2, Lin-Fu Liang3
1State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, China; The First Affiliated Hospital of Jinzhou Medical University, 2 Renmin Road, Jinzhou 121001, China.
Abstract:
3-Nor-spongiolide A (1), belonging to the extremely rare 3-nor-spongian carbon skeleton, and spongiolides A (2) and B (3), having γ-butenolide instead of furan ring as usual for ring D, together with six related known metabolites were isolated from South China Sea sponge Spongia officinalis as its metabolic components. Their structures were elucidated on the basis of extensive spectroscopic analysis. The absolute configurations of three new compounds 1-3 were determined by ECD calculations.
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