Related Experiment Video
Updated: Feb 14, 2026
09:18
A Comparative Study of Drug Delivery Methods Targeted to the Mouse Inner Ear: Bullostomy Versus Transtympanic Injection
Published on: March 8, 2017
14.1K
A long-term comparative prospective study between reinnervation and injection laryngoplasty
1Department of Otolaryngology-Head and Neck Surgery, Soonchunhyang University College of Medicine, Bucheon, Republic of Korea.
The Laryngoscope
|February 17, 2018
Summary
Recurrent laryngeal nerve reinnervation (RLNR) offers superior long-term voice outcomes compared to injection laryngoplasty (IL) for thyroidectomy-related vocal fold paralysis. RLNR provides stable voice improvements up to 36 months post-surgery.
Area of Science:
- Otolaryngology
- Vocal Cord Surgery
- Neurosurgery
Background:
- Thyroidectomy can lead to unilateral vocal fold paralysis (VFP), impacting voice quality.
- Management options for VFP include injection laryngoplasty (IL) and recurrent laryngeal nerve reinnervation (RLNR).
- Long-term voice outcome comparisons between these methods are crucial for clinical decision-making.
Purpose of the Study:
- To compare and assess the long-term voice outcomes of injection laryngoplasty (IL) versus recurrent laryngeal nerve reinnervation (RLNR) in patients with thyroidectomy-related unilateral vocal fold paralysis (VFP).
Main Methods:
- A prospective clinical study was conducted from March 2005 to January 2016.
- Nineteen patients underwent RLNR (ansa cervicalis or direct reinnervation).
- Forty-three patients underwent IL for unilateral VFP.
Main Results:
- Both IL and RLNR demonstrated statistically significant voice improvements at 36 months post-surgery.
- Voice parameters improved with IL up to 36 months, but some deterioration was noted after 24 months.
- RLNR showed sustained and stable voice improvements up to 36 months without deterioration.
Conclusions:
- Both RLNR and IL provide significant voice improvements for unilateral vocal fold paralysis.
- Recurrent laryngeal nerve reinnervation (RLNR) yields superior and more stable long-term voice results compared to injection laryngoplasty (IL) at 36 months postoperatively.
More Related Videos
Related Concept Videos
01:05Long-term Depression
33.4K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
33.4K
01:03Long-term Depression
3.4K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
Calcium Ion Concentration Mechanism
If over...
3.4K
02:26Comparing Copy Number Variations and SNPs
18.8K
Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
18.8K
02:24Comparative Excretory Systems
26.7K
Animals have evolved different strategies for excretion, the removal of waste from the body. Most waste must be dissolved in water to be excreted, so an animal’s excretory strategy directly affects its water balance.
26.7K
01:09Comparing Experimental Results: Student's t-Test
6.1K
The t-test is a statistical method used to compare the sample mean with a population mean or compare two means from two data sets. The test statistic is calculated from the standard deviation, mean, and number of measurements in the data set at a selected confidence interval and then compared to a table of critical values at this confidence level. If the test statistic is smaller than the critical value, the null hypothesis is accepted. In this case, we state that the difference between the...
6.1K
01:20Comparing the Survival Analysis of Two or More Groups
619
Survival analysis is a cornerstone of medical research, used to evaluate the time until an event of interest occurs, such as death, disease recurrence, or recovery. Unlike standard statistical methods, survival analysis is particularly adept at handling censored data—instances where the event has not occurred for some participants by the end of the study or remains unobserved. To address these unique challenges, specialized techniques like the Kaplan-Meier estimator, log-rank test, and...
619