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Does Intralesional Steroid Injection Effectively Mitigate Vocal Fold Scarring in A Rabbit Model?
Jun-Yeong Jeong1, Samjhana Thapa2, Seung-Won Lee1
1Department of Otolaryngology - Head and Neck Surgery, Soonchunhyang University College of Medicine, Bucheon, Korea.
The Laryngoscope
|October 1, 2024
Summary
Intralesional steroid injections effectively reduced vocal fold scarring after surgery in rabbits. This treatment improved vocal fold function and reduced collagen density, offering a promising approach for preventing scarring.
Area of Science:
- Otolaryngology
- Regenerative Medicine
- Surgical Innovation
Background:
- Vocal fold surgery can lead to scarring, impairing voice function.
- Preventing post-surgical scarring is crucial for optimal voice outcomes.
- Current treatments for vocal fold scarring are limited.
Purpose of the Study:
- To evaluate the efficacy of intralesional steroid injections in preventing vocal fold scarring post-surgery.
- To assess the impact of dexamethasone and triamcinolone on vocal fold healing and function in a rabbit model.
Main Methods:
- 42 New Zealand white rabbits underwent vocal fold scar surgery.
- Groups received either no treatment (control), dexamethasone, or triamcinolone injections.
- Vocal fold function, histology, and gene expression (Has-2, Mmp-9) were analyzed after 4 weeks.
Main Results:
- Steroid-treated groups showed significantly higher maximum amplitude of vibration compared to controls.
- Histological analysis revealed reduced collagen density in steroid-treated groups.
- Real-time PCR indicated increased Has-2 and Mmp-9 expression in response to steroid treatment.
Conclusions:
- Intralesional steroid injections are effective in reducing vocal fold scarring in a rabbit model.
- This approach shows potential for improving functional outcomes after vocal fold surgery.
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