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Updated: Jul 14, 2025

Construction and Characterization of a Novel Vocal Fold Bioreactor
Published on: August 1, 2014
A Novel Intervention That Prevents Vocal Fold Scarring
Jun-Yeong Jeong1, Ki-Nam Park1, Seung-Won Lee1
1Department of Otolaryngology-Head and Neck Surgery, Soonchunhyang University College of Medicine, Bucheon, South Korea.
Stromal vascular fraction (SVF) injection demonstrated preventive effects on vocal fold scar in rabbits. SVF improved vocal fold vibration and reduced scar tissue, offering a potential therapeutic strategy.
Area of Science:
- Regenerative Medicine
- Otorhinolaryngology
- Tissue Engineering
Background:
- Vocal fold scarring can impair voice quality.
- Current treatments for vocal fold scar have limitations.
Purpose of the Study:
- To evaluate the preventive efficacy of stromal vascular fraction (SVF) for vocal fold scar.
- To assess the impact of SVF on vocal fold vibration and scar tissue characteristics in a rabbit model.
Main Methods:
- A rabbit model of vocal fold scar was established.
- Stromal vascular fraction (SVF) was injected into the vocal folds of the treatment group.
- Vocal fold vibration, histology, and gene expression (TGF-ß1, IL-6, procollagen-1, MMP-2, 9, HAS-2, 3) were analyzed.
Main Results:
- SVF injection significantly improved vocal fold vibration amplitude.
- Histological analysis revealed reduced collagen density in the SVF group.
- Gene expression analysis showed modulation of scar-related markers, including increased MMPs and HASs, and decreased TGF-ß1, IL-6, and procollagen-1.
Conclusions:
- SVF injection demonstrated preventive activity against vocal fold scarring in a rabbit model.
- SVF treatment led to improved vocal fold vibration and favorable changes in scar tissue characteristics.
- SVF represents a promising therapeutic approach for vocal fold scar management.
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