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Updated: Feb 14, 2026
Surface Functionalization of Hepatitis E Virus Nanoparticles Using Chemical Conjugation Methods
Published on: May 11, 2018
Proposal for a new subtype of the zoonotic genotype 3 Hepatitis E virus: HEV-3l
Luca De Sabato1, Philippe Lemey2, Bram Vrancken2
1Istituto Superiore di Sanità, Department of Food Safety, Nutrition and Veterinary Public Health, Viale Regina Elena, 299, 00161, Rome, Italy; University Roma Tre, Department of Sciences, Viale Guglielmo Marconi 446, 00146 Rome, Italy.
Abstract:
The near-complete genomic sequences of two hepatitis E virus (HEV) strains, detected from feces of infected pigs, were obtained. Phylogenetic analysis and p-distance comparisons of the complete coding regions showed a close relationship to the French swine strain FR-SHEV3c-like detected in 2006 (p-distance value 0.101), belonging to HEV-3 but not assigned to any known subtype. The three HEV sequences showed, relatively high nucleotide distances (p-distance >0.129) compared to the other defined HEV subtype references and unclassified strains. The HEV classification criteria and the high sequence similarity suggest that these strains can be assigned to a putative novel subtype of genotype 3, HEV-3l.
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