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Seminal bacterial composition in patients with obstructive and non-obstructive azoospermia
Houyang Chen1,2, Tao Luo3, Tingtao Chen4
1Department of Urology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China.
Experimental and Therapeutic Medicine
|February 20, 2018
Summary
The seminal microbiome differs in men with azoospermia, showing altered bacterial populations. This research explores these changes to aid in diagnosing and treating azoospermia.
Area of Science:
- Microbiology
- Urology
- Genomics
Background:
- Previous studies suggest the seminal microbiome is more complex than previously thought.
- Understanding the seminal microbiome is crucial for male reproductive health.
Purpose of the Study:
- To profile the seminal microbiome in patients with obstructive azoospermia (OA) and non-obstructive azoospermia (NOA).
- To compare the seminal microbiome composition between healthy individuals and azoospermic patients.
Main Methods:
- High-throughput sequencing of genomic DNA from semen samples.
- Analysis of bacterial communities in healthy controls (C), OA patients, and NOA patients.
Main Results:
- Firmicutes, Proteobacteria, Bacteroidetes, and Actinobacteria dominated all groups.
- OA and NOA groups showed increased Bacteroidetes and Firmicutes, with decreased Proteobacteria and Actinobacteria compared to controls.
- 398 common operational taxonomic units were identified, including 27 from the Lactobacillus genus.
Conclusions:
- Azoospermia is associated with significant alterations in the seminal microbiome.
- Reduced biodiversity and presence of pathogenic species may increase risks for metabolic, infectious, and immune diseases.
- Seminal microbiome profiling offers potential for novel azoospermia diagnosis and treatment strategies.
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