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Nail Changes in Early Mycosis Fungoides
Amir Hooshang Ehsani1, Maryam Nasimi1, Arghavan Azizpour1
1Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Skin Appendage Disorders
|February 20, 2018
Summary
Nail changes are common in patients with mycosis fungoides (MF), affecting 30% of cases. Longitudinal ridging, thickening, fragility, and leukonychia are the most frequent nail alterations observed in MF patients.
Area of Science:
- Dermatology
- Oncology
- Pathology
Background:
- Mycosis fungoides (MF) presents with diverse clinical manifestations.
- Nail apparatus involvement in MF is infrequently reported.
Purpose of the Study:
- To determine the incidence and specific characteristics of nail abnormalities in patients diagnosed with mycosis fungoides.
- To correlate nail changes with clinical presentation and histological findings in MF.
Main Methods:
- Retrospective analysis of 60 biopsy-proven mycosis fungoides (MF) patients from 2013-2014.
- Identification of patients with nail apparatus involvement.
- Histopathological examination of periungual skin in selected cases.
Main Results:
- Nail changes were observed in 18 out of 60 (30%) MF patients.
- Common nail alterations included longitudinal ridging, thickening, fragility, and leukonychia.
- Periungual skin changes were present in 15 patients, with 13 exhibiting associated nail abnormalities.
Conclusions:
- Nail changes are a notable finding in a significant proportion of mycosis fungoides patients.
- Specific nail alterations like longitudinal ridging, thickening, fragility, and leukonychia are characteristic.
- Histological examination of periungual skin did not confirm MF involvement in the studied cases.
