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Published on: January 15, 2018
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Functional and Modified Nanocrystals Technology for Target Drug Delivery.
Juan Zhao1, Yangyang Liu1, Lulu Wang1
1School of Chemistry and Pharmaceutical Engineering, Qilu University of Technology, Jinan 250353, China.
Journal of Nanoscience and Nanotechnology
|February 21, 2018
Summary
Drug nanocrystals overcome poor solubility, enhancing bioavailability and dissolution. This review explores advanced modification technologies for targeted drug delivery, improving stability and control.
Area of Science:
- Pharmaceutical Science
- Nanotechnology
- Drug Delivery Systems
Background:
- Poorly soluble drugs limit therapeutic applications.
- Nanocrystal technology offers a viable solution to enhance drug solubility, dissolution velocity, and bioavailability.
- Existing research covers nanocrystal preparation, safety, and administration routes.
Purpose of the Study:
- To systematically review current nanocrystal technologies for targeted drug delivery.
- To analyze the impact of surface modification on nanocrystal performance.
- To provide insights for improving nanocrystal stability and controllability in drug targeting.
Main Methods:
- Review of advanced nanocrystal modification technologies.
- Analysis of surface charge and particle size effects on targeted administration.
- Inclusion of magnetic, PEGylated chitosan, cationic, and pluronic modified nanocrystals.
Main Results:
- Various surface modification strategies enhance nanocrystal efficacy for targeted delivery.
- Surface charge and particle size are critical factors influencing drug targeting.
- Modified nanocrystals demonstrate improved potential for drug delivery applications.
Conclusions:
- Nanocrystal technology is crucial for overcoming drug solubility challenges.
- Surface modification techniques are key to achieving targeted drug delivery.
- Further development in nanocrystal stability and controllability will advance targeted drug delivery systems.
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