Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Fixing Double-strand Breaks

Fixing Double-strand Breaks

The double-stranded structure of DNA has two major advantages. First, it serves as a safe repository of genetic information where one strand serves as the back-up in case the other strand is damaged. Second, the double-helical structure can be wrapped around proteins called histones to form nucleosomes, which can then be tightly wound to form chromosomes. This way, DNA chains up to 2 inches long can be contained within microscopic structures in a cell. A double-stranded break not only damages...

Fixing Double-strand Breaks

Fixing Double-strand Breaks

Double Resonance Techniques: Overview

Double Resonance Techniques: Overview

Double resonance techniques in Nuclear Magnetic Resonance (NMR) spectroscopy involve the simultaneous application of two different frequencies or radiofrequency pulses to manipulate and observe two distinct nuclear spins. One important application of double resonance is spin decoupling, which selectively suppresses coupling with one type of nucleus while observing the NMR signal from another nucleus, simplifying the spectrum and enhancing resolution.
Spin decoupling is usually achieved by...

Frustration and Conflict: Avoidance-Avoidance, Double-Approach Avoidance

Frustration and Conflict: Avoidance-Avoidance, Double-Approach Avoidance

Avoidance-avoidance conflict refers to a psychological situation where a person must choose between two or more unpleasant alternatives. These conflicts are particularly stressful because neither option is desirable. This dilemma is often expressed in sayings like "caught between a rock and a hard place" or "between the devil and the deep blue sea." For instance, individuals who fear dental procedures may find themselves torn between enduring a painful toothache or facing the...

Probability Laws

Probability Laws

Punnett Squares

Punnett Squares

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

First-principles study of Y<sub>2</sub>CCl<sub>2</sub> and Janus Y<sub>2</sub>CClX (X = F, Br, I) MXenes for photovoltaic applications.

Scientific reports·2026

Same author

Outcome of Conservative Management of Pancreatic Pseudocyst.

Mymensingh medical journal : MMJ·2026

Same authorSame journal

The Correlation between Exposure to Screen Time and Severity of Autism Spectrum Disorder in Children in Bangladesh: A Case-Control Study.

Mymensingh medical journal : MMJ·2026

Same author

First-principles investigation of direct band gap double perovskite halides A<sub>2</sub>AgIrCl<sub>6</sub> (A = Cs, Rb, K) for enhanced photovoltaic performance.

RSC advances·2026

Same author

Comparative Outcomes of Resection: Primary Anastomosis and Hartmann's Procedure in the Management of Sigmoid Volvulus.

Mymensingh medical journal : MMJ·2026

Same author

Perioperative and Postoperative Complications Associated with Stapled Hemorrhoidopexy.

Mymensingh medical journal : MMJ·2026

Search research articles

Related Experiment Video

Updated: Feb 14, 2026

Engineering Oncogenic Heterozygous Gain-of-Function Mutations in Human Hematopoietic Stem and Progenitor Cells

Engineering Oncogenic Heterozygous Gain-of-Function Mutations in Human Hematopoietic Stem and Progenitor Cells

Published on: March 10, 2023

Double Heterozygous For Haemoglobin S and Haemoglobin E.

M M Rahman¹, K Fatema, M M Hossain

¹Colonel (Dr) Mohammad Mizanur Rahman, Classified Specialist in Pathology, Department of Haematology, Armed Forces Institute of Pathology (AFIP), Dhaka Cantonment, Dhaka, Bangladesh;

Mymensingh Medical Journal : MMJ

|February 21, 2018

Summary

A rare double heterozygous state for hemoglobin S (HbS) and hemoglobin E (HbE) was identified in a Bangladeshi family. Documenting this uncommon genetic condition is crucial for family genetic counseling and reproductive risk assessment.

More Related Videos

Isolation of Double Negative αβ T Cells from the Kidney

Isolation of Double Negative αβ T Cells from the Kidney

Published on: May 16, 2014

Confocal Imaging of Double-Stranded RNA and Pattern Recognition Receptors in Negative-Sense RNA Virus Infection

Confocal Imaging of Double-Stranded RNA and Pattern Recognition Receptors in Negative-Sense RNA Virus Infection

Published on: January 26, 2019

Related Experiment Videos

Last Updated: Feb 14, 2026

Engineering Oncogenic Heterozygous Gain-of-Function Mutations in Human Hematopoietic Stem and Progenitor Cells

Engineering Oncogenic Heterozygous Gain-of-Function Mutations in Human Hematopoietic Stem and Progenitor Cells

Published on: March 10, 2023

Isolation of Double Negative αβ T Cells from the Kidney

Isolation of Double Negative αβ T Cells from the Kidney

Published on: May 16, 2014

Confocal Imaging of Double-Stranded RNA and Pattern Recognition Receptors in Negative-Sense RNA Virus Infection

Confocal Imaging of Double-Stranded RNA and Pattern Recognition Receptors in Negative-Sense RNA Virus Infection

Published on: January 26, 2019

Area of Science:

Hematology
Medical Genetics

Background:

Hemoglobin E (HbE) is prevalent in Bangladesh, while Hemoglobin S (HbS) is rare.
Co-inheritance of HbS and HbE is uncommon in the region, unlike HbE/β-thalassemia.

Observation:

A Bangladeshi family study identified two members with a double heterozygous state for HbS and HbE.
Other family members presented with single HbS or HbE gene inheritance.

Findings:

The study confirmed a rare double heterozygous state for HbS and HbE in a family.
This genetic condition, though uncommon, was documented in Dhaka, Bangladesh.

Implications:

Documentation of rare HbS/HbE double heterozygosity is vital for genetic counseling.
Understanding reproductive risks associated with this condition is important for affected families.