[Concurrent lymphocytic colitis and microscopic enteritis in patients with chronic diarrhea]
Fernando Arévalo1, Greys Vergara2, Susy Ruiz3
1Servicio de Patología, Hospital Nacional Daniel Alcides Carrión. Callao, Perú; Universidad Nacional Mayor de San Marcos. Lima, Perú.
Summary
This study reports the first known cases of coexisting lymphocytic colitis and microscopic enteritis. These findings suggest a potential generalized gastrointestinal disorder affecting both the large and small intestines in patients with chronic diarrhea.
Area of Science:
- Gastroenterology
- Pathology
- Immunology
Background:
- Lymphocytic colitis and microscopic enteritis are common causes of chronic diarrhea.
- Both conditions are characterized by an intraepithelial lymphocytic infiltrate.
- No prior reports documented the coexistence of these two pathologies.
Purpose of the Study:
- To describe the histological and clinical characteristics of patients with coexisting lymphocytic colitis and microscopic enteritis.
- To investigate the immune cell profile in these coexisting conditions.
Main Methods:
- Retrospective review of 35 patients diagnosed with simultaneous lymphocytic duodenitis and colitis (2010-2016).
- Histological slides re-evaluated by three pathologists.
- Immunohistochemical analysis of CD3 and CD8 expression in six cases.
Main Results:
- Coexistence of lymphocytic duodenitis and colitis identified in 35 patients (80% female).
- Anemia (28.5%) and Blastocystis hominis infestation (31.8%) were noted.
- Lymphocytic ileitis and eosinophilic colitis were also diagnosed in a subset of patients.
Conclusions:
- Lymphocytic colitis, microscopic enteritis, and lymphocytic ileitis can coexist in patients with chronic diarrhea.
- This concurrence raises questions about a potential generalized gastrointestinal disorder affecting both small and large intestines.
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