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Non-syndromic single-suture craniosynostosis in triplets
David Chesler1, Richard Bram2, Prince Antwi3
1Departments of Neurological Surgery and Pediatrics, Stony Brook University School of Medicine, Stony Brook, NY, 11794-8122, USA. david.chesler@stonybrookmedicine.edu.
This study reports the first case of triplets with non-syndromic craniosynostosis. Genetic testing did not reveal mutations, suggesting epigenetic or environmental factors may contribute to this rare condition.
Area of Science:
- Genetics
- Developmental Biology
- Pediatric Surgery
Background:
- Craniosynostosis involves premature fusion of cranial sutures, with causes often attributed to genetic, epigenetic, and environmental interactions.
- While genetic factors are implicated, less than 100% concordance in identical twins suggests other influences.
- This is the first report of non-syndromic single-suture craniosynostosis in all three children of a triplet set.
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