Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Peripheral Nervous System: Ganglia and Nerves01:24

Peripheral Nervous System: Ganglia and Nerves

5.8K
The Peripheral Nervous System (PNS) is a crucial component of the body's neural network, extending beyond the central nervous system (CNS) to bridge the gap between the CNS and the external environment. It encompasses nerves, ganglia, and sensory receptors.
Nerves
The nerve is a bundle of axons that serves as the communication highway in the PNS. Each nerve is ensheathed in a protective layer of connective tissue called the epineurium. This outermost layer safeguards the nerve and supports the...
5.8K
Carbon Skeletons01:12

Carbon Skeletons

115.6K
Life on Earth is carbon-based, as all macromolecules that make up living organisms contain carbon atoms. All organic compounds have a carbon backbone. Each carbon atom is tetravalent and can bond with four other atoms, making it an extraordinarily flexible component of biological molecules. Because carbon’s valence electrons are stable, it rarely becomes an ion. As the carbon chain increases in length, structural modifications such as ring structures, double bonds, and branching side...
115.6K
Protein-protein Interfaces02:04

Protein-protein Interfaces

14.8K
Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
14.8K
Protein-Protein Interfaces02:04

Protein-Protein Interfaces

4.5K
4.5K
The Carbon Cycle01:14

The Carbon Cycle

44.1K
Carbon is the basis of all organic matter on Earth, and is recycled through the ecosystem in two primary processes: one in which carbon is exchanged among living organisms, and one in which carbon is cycled over long periods of time through fossilized organic remains, weathering of rocks, and volcanic activity. Human activities, including increased agricultural practices and the burning of fossil fuels, has greatly affected the balance of the natural carbon cycle.
44.1K
Standard Electrode Potentials03:02

Standard Electrode Potentials

50.5K
On comparing the reactivity of silver and lead, it is observed that the two ionic species, Ag+ (aq) and Pb2+ (aq), show a difference in their redox reactivity towards copper: the silver ion undergoes spontaneous reduction, while the lead ion does not. This relative redox activity can be easily quantified in electrochemical cells by a property called cell potential. This property is commonly known as cell voltage in electrochemistry, and it is a measure of the energy which accompanies the charge...
50.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Anti-seizure medications and DRESS in paediatric patients: A FAERS disproportionality and time-to-onset analysis.

British journal of clinical pharmacology·2026
Same author

Prevalence of <i>Toxoplasma gondii</i> in Chinese stray dogs: a meta-analysis.

Open veterinary journal·2026
Same author

High-Electron-Insulating Li<b><sub>2</sub></b>O-Assisted Li<b><sub>3</sub></b>N for Highly Stable SEI Formation in High-Performance Li-S Batteries.

Inorganic chemistry·2026
Same author

Polysaccharide-Protein Complex from <i>Sargassum fusiforme</i>: Fractionation, Characterization, and Hypoglycemic Activity.

Journal of agricultural and food chemistry·2026
Same author

Structure-Based Drug Design to Identify Potent, Selective, and Orally Available Cyclin-Dependent Kinase 9 Inhibitors for the Treatment of Castration-Resistant Prostate Cancer.

Journal of medicinal chemistry·2026
Same author

Comprehensive analysis of mutational signatures and corresponding driver genes in cervical cancer from Xinjiang.

Biochemistry and biophysics reports·2026

Related Experiment Video

Updated: Feb 14, 2026

The Muscle Cuff Regenerative Peripheral Nerve Interface for the Amplification of Intact Peripheral Nerve Signals
07:30

The Muscle Cuff Regenerative Peripheral Nerve Interface for the Amplification of Intact Peripheral Nerve Signals

Published on: January 13, 2022

2.5K

Flexible 3D carbon nanotubes cuff electrodes as a peripheral nerve interface.

Pan Tian1, Wenwen Yi2, Chaoyang Chen3

  • 1State Key Laboratory of Mechanical System and Vibration, Shanghai Jiao Tong University, Shanghai, China.

Biomedical Microdevices
|February 21, 2018
PubMed
Summary

Researchers developed a novel 3D carbon nanotube (CNT) cuff electrode for peripheral nerve stimulation. This flexible CNT electrode demonstrates superior performance compared to traditional platinum electrodes in animal studies.

Keywords:
Carbon nanotubesCuff electrodeParylenePeripheral nerve interface

More Related Videos

Implantation and Control of Wireless, Battery-free Systems for Peripheral Nerve Interfacing
07:13

Implantation and Control of Wireless, Battery-free Systems for Peripheral Nerve Interfacing

Published on: October 20, 2021

4.0K
Fabrication of High Contact-Density, Flat-Interface Nerve Electrodes for Recording and Stimulation Applications
09:35

Fabrication of High Contact-Density, Flat-Interface Nerve Electrodes for Recording and Stimulation Applications

Published on: October 4, 2016

10.2K

Related Experiment Videos

Last Updated: Feb 14, 2026

The Muscle Cuff Regenerative Peripheral Nerve Interface for the Amplification of Intact Peripheral Nerve Signals
07:30

The Muscle Cuff Regenerative Peripheral Nerve Interface for the Amplification of Intact Peripheral Nerve Signals

Published on: January 13, 2022

2.5K
Implantation and Control of Wireless, Battery-free Systems for Peripheral Nerve Interfacing
07:13

Implantation and Control of Wireless, Battery-free Systems for Peripheral Nerve Interfacing

Published on: October 20, 2021

4.0K
Fabrication of High Contact-Density, Flat-Interface Nerve Electrodes for Recording and Stimulation Applications
09:35

Fabrication of High Contact-Density, Flat-Interface Nerve Electrodes for Recording and Stimulation Applications

Published on: October 4, 2016

10.2K

Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Neuroscience

Background:

  • Cuff electrodes offer stable peripheral nerve interfaces, crucial for research and clinical applications.
  • Existing microfabrication methods for cuff electrodes are limited by planar processing.
  • Developing advanced electrode materials is key to improving nerve stimulation efficacy.

Purpose of the Study:

  • To present a novel cuff electrode design utilizing high-aspect ratio carbon nanotubes (CNTs) on a flexible substrate.
  • To overcome the limitations of planar microfabrication in current cuff electrode technology.
  • To evaluate the performance of the novel CNT cuff electrode in peripheral nerve stimulation.

Main Methods:

  • Fabrication of cuff electrodes by integrating vertically grown CNTs onto a biocompatible parylene substrate.
  • A microfabrication process combining high-temperature CNT growth with a heat-sensitive parylene substrate.
  • In vivo testing of the CNT cuff electrodes for extracellular nerve stimulation in a rat model.

Main Results:

  • The novel CNT cuff electrode demonstrated superior performance in nerve stimulation compared to traditional platinum electrodes.
  • The study analyzed the impact of electrode positioning and stimulation frequency on nerve stimulation outcomes.
  • Preliminary data suggests the 3D CNT cuff electrode is a promising platform for functional electrical stimulation.

Conclusions:

  • Flexible 3D carbon nanotube cuff electrodes represent a significant advancement over planar designs.
  • The developed microfabrication technique enables controllable integration of CNTs on flexible substrates.
  • This technology offers a promising platform for enhanced functional electrical stimulation applications.