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Updated: Feb 14, 2026

Three-dimensional Quantification of Intestinal Mucus Using Whole-mount Tissue Imaging
Published on: September 12, 2025
[MICROECOLOGICAL CHANGES IN THE INTESTINE AND ITS EFFECT ON THE CONDITION OF HARD TISSUES OF TEETH IN ADOLESCENCE]
T Shishniashvili1, T Suladze1, M Makhviladze1
1Tbilisi State Medical University, Georgia.
Abstract:
On the background of microecological changes in the gastrointestinal tract, mineral and protein metabolism is disrupted, biochemical changes occur in the phosphorus-calcium metabolism in the bones of the skeleton and hard tissues of the teeth. The aim of the research was to study the activity of the caries process, characterized by progressive decalcification, under conditions of microecological changes in the intestine and its effect on the processes of endogenous calcium assimilation in adolescence. Within the frames of the research 68 adolescents aged 11 to 17 years with various degrees of pathology of the gastrointestinal tract were examined. The data of the performed studies showed that in patients with more severe changes in the intestinal micro flora, the prevalence and intensity of dental caries are significantly higher (83.4% on average DMFT 5.0) than in adolescents with mild dysbiosis (71.8% DMFT 3.2% ), and in the patients with normal intestinal micro flora - the parameters were minimal. Estimating and comparing the interrelation between the incidence of caries and the presence of diseases of the gastrointestinal tract in adolescents, a directly proportional dependence of the DMF index on age was found, but the greatest increase in the individual level of incidence of dental caries (SIC) was observed in adolescents aged 14-16 (SIC=0,42) with severe gastrointestinal pathology GIT. Thus, significant changes in dental status detected in adolescents with pathology of the gastrointestinal tract confirm the validity of complex treatment and preventive dental care, considering the processes occurring in the body and the oral cavity, as well as the systematic, purposeful dental care and the allocation of patients with gastrointestinal pathology (GIT) in a separate group.
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