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Scaling Physiologic Function from Cell to Tissue in Asthma, Cancer, and Development.
Yasha Sharma1, Lior Atia1, Christalyn Sims Rhodes1
1Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
Annals of the American Thoracic Society
|February 21, 2018
Summary
Cellular collective migration, crucial for tissue formation, is explored through cell jamming and unjamming dynamics. Understanding these processes clarifies how cell groups move together to build functional tissues.
Area of Science:
- Cell Biology
- Biophysics
- Developmental Biology
Background:
- Tissue formation requires coordinated cell behavior, involving individual cell properties and collective interactions.
- Key processes include cell sorting, tissue assembly, and collective cell migration.
Purpose of the Study:
- To elucidate the mechanisms underlying collective cellular migration.
- To investigate the role of cell jamming and unjamming in collective cell movement.
Main Methods:
- Analysis of cell sorting governed by differential adhesion.
- Examination of tissue assembly via epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET).
- Theoretical consideration of cell jamming and unjamming transitions.
Main Results:
- Differential adhesion drives cell sorting.
- EMT/MET controls tissue assembly.
- Cell jamming and unjamming are proposed as key mechanisms for collective cell migration.
Conclusions:
- Collective cell migration mechanisms were previously unclear.
- Cell jamming and unjamming provide a mechanistic framework for collective cell migration.
- This understanding is vital for tissue development and regeneration.
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