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Related Concept Videos

Transdermal Drug Delivery Systems01:18

Transdermal Drug Delivery Systems

4
Transdermal drug delivery systems (TDDS) enable the controlled release of drugs across the skin into systemic circulation. They are particularly advantageous for drugs with short half-lives or narrow therapeutic indices, as they maintain consistent plasma concentrations and reduce the risk of subtherapeutic or toxic levels.TDDS are categorized into monolithic, reservoir, and mixed systems. Monolithic systems embed the drug in a polymer matrix, where diffusion governs release. Reservoir systems...
4
Ophthalmic Drug Delivery Systems01:23

Ophthalmic Drug Delivery Systems

4
Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...
4
Intrauterine Drug Delivery Systems01:21

Intrauterine Drug Delivery Systems

3
Controlled-release systems for intravaginal and intrauterine drug delivery have been developed primarily for the administration of contraceptive steroid hormones. These delivery routes circumvent first-pass hepatic metabolism, thereby enhancing bioavailability and allowing for reduced systemic dosages compared to oral administration. Such approaches contribute to improved therapeutic efficacy and patient compliance, particularly in long-term contraceptive regimens.Intravaginal Drug Delivery...
3
Drug Delivery Systems: Different Types01:27

Drug Delivery Systems: Different Types

2
Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...
2
Oral Drug Delivery Systems: Continuous-Release Systems01:26

Oral Drug Delivery Systems: Continuous-Release Systems

2
Continuous-release drug delivery systems offer a strategic approach to maintaining therapeutic drug levels over extended periods following oral administration. By modulating the release rate of active pharmaceutical ingredients, these systems minimize fluctuations in plasma concentrations, which enhances clinical efficacy and reduces the need for frequent dosing. Such characteristics make them particularly advantageous in managing chronic diseases where patient adherence and stable drug...
2
Oral Drug Delivery Systems: Delayed-Release Systems01:11

Oral Drug Delivery Systems: Delayed-Release Systems

3
Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...
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Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers
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DNA Nanotechnology-Enabled Drug Delivery Systems.

Qinqin Hu1,2, Hua Li3,4, Lihua Wang5,6

  • 1Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Fudan University , Shanghai 200032 , China.

Chemical Reviews
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Summary
This summary is machine-generated.

DNA nanotechnology enables precise self-assembly of nanostructures for enhanced drug delivery, improving targeting and reducing toxicity. This field holds significant promise for nanomedicine applications.

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Area of Science:

  • Biomedical nanotechnology
  • DNA nanotechnology
  • Nanomedicine

Background:

  • Nanotechnology has advanced biomedical applications like bioimaging, biodetection, and drug delivery.
  • DNA nanotechnology offers design techniques for self-assembling nanostructures with controllable properties.
  • DNA nanostructures show potential for enhancing drug targeting and reducing toxicity.

Purpose of the Study:

  • To review the origin and construction strategies of DNA nanostructures.
  • To summarize drug payloads and delivery methods using DNA nanovehicles.
  • To discuss the cellular fate, challenges, and opportunities in DNA nanostructure-based drug delivery.

Main Methods:

  • Review of literature on DNA nanotechnology.
  • Analysis of sequence programming and optimization for nanostructure design.
  • Examination of drug loading and delivery mechanisms using DNA nanostructures.

Main Results:

  • DNA nanostructures can be precisely engineered for size, shape, and function.
  • Anticancer drugs like Doxorubicin and CpG oligonucleotides have been loaded onto DNA nanostructures.
  • Increased cell uptake efficiency of loaded drugs has been demonstrated.

Conclusions:

  • DNA nanotechnology is a rapidly advancing field with significant potential in nanomedicine.
  • DNA nanovehicles offer a promising platform for targeted drug delivery.
  • Further research is needed to address challenges and explore opportunities in this area.