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Related Experiment Videos

Sulindac-associated small bowel lesion.

H J Freeman

    Journal of Clinical Gastroenterology
    |October 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Sulindac use can cause drug-related small bowel disease, presenting as diarrhea and mucosal lesions. Symptoms resolved upon medication withdrawal and returned with re-administration, highlighting a potential cause for "flat" mucosal lesions.

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    Area of Science:

    • Gastroenterology
    • Pharmacology
    • Pathology

    Background:

    • Celiac sprue is a well-known cause of small intestinal mucosal lesions.
    • Drug-induced enteropathies are increasingly recognized as a cause of gastrointestinal symptoms.

    Observation:

    • A patient presented with diarrhea and a small bowel lesion histologically similar to celiac sprue.
    • The patient was concurrently taking the nonsteroidal anti-inflammatory drug sulindac.

    Findings:

    • Discontinuation of sulindac led to complete resolution of symptoms and biopsy abnormalities.
    • Re-administration of sulindac resulted in prompt recurrence of both symptoms and pathological findings.

    Implications:

    • This case suggests sulindac can induce a distinct form of drug-related small bowel disease.

    Related Experiment Videos

  • Clinicians should consider sulindac-induced enteropathy in patients with unexplained "flat" small intestinal mucosal lesions.
  • This expands the differential diagnosis for villous atrophy and malabsorption syndromes.