Related Experiment Video
Updated: Feb 14, 2026

Site Directed Spin Labeling and EPR Spectroscopic Studies of Pentameric Ligand-Gated Ion Channels
Published on: July 4, 2016
[Bullosis diabeticorum : Two case studies]
G Wagner1, V Meyer2, M M Sachse2
1Klinik für Dermatologie, Allergologie und Phlebologie, Klinikum Bremerhaven Reinkenheide, Postbrookstr. 103, 27574, Bremerhaven, Deutschland. gunnar.wagner@klinikum-bremerhaven.de.
Bullosis diabeticorum, a rare skin condition in diabetic patients, causes blister formation on the hands and feet. Early diagnosis and exclusion of other conditions are crucial for managing this diabetic complication.
Area of Science:
- Dermatology
- Endocrinology
Background:
- Bullosis diabeticorum is a rare condition characterized by blister formation, primarily affecting diabetic patients.
- It typically presents on the palmoplantar regions of the hands and feet.
Observation:
- Two cases of diabetes mellitus patients presented with bullae on fingers or toes.
- The bullae measured up to 2 cm in diameter and contained clear to hemorrhagic fluid.
Findings:
- Differential diagnoses were excluded, leading to the classification as bullosis diabeticorum.
- Histopathological examination revealed both intraepidermal and subepidermal bullae without significant inflammation.
- Lesions generally heal without scarring, though postinflammatory pigmentation or tender scars can occur.
Implications:
- This report highlights the clinical presentation and diagnostic considerations for bullosis diabeticorum in diabetic individuals.
- Further research into the etiopathogenesis of bullosis diabeticorum is warranted to understand its development in diabetes mellitus.
Related Concept Videos
Case Studies
Imaging Studies I: Kidney, Ureter, and Bladder Studies
Longitudinal Studies
Observational Studies
There are three types of observational studies – Prospective, retrospective, and cross-sectional.
Prospective Study
Prospective studies, also known as longitudinal or cohort studies, are carried out by collecting future data from groups sharing similar characteristics. One...
Studying the Cytoskeleton
Bioavailability Study Design: Single Versus Multiple Dose Studies

