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[Methodology for a controlled trial in Alzheimer's disease]
Presse Medicale (Paris, France : 1983)
|September 25, 1986
Summary
This study proposes a new protocol for Alzheimer's disease clinical trials, combining assessments for better patient selection and tracking. The goal is to quantify disease progression over one year, despite challenges in understanding its natural history.
Area of Science:
- Neurology
- Clinical Trials
- Geriatrics
Background:
- Existing evaluation scales for Alzheimer-like dementias are debated.
- Practical considerations for controlled trials are being addressed.
Purpose of the Study:
- To design a tentative protocol for Alzheimer's disease clinical trials.
- To facilitate multicenter studies with easily manageable evaluation tools.
- To enable selection of homogeneous patient groups and quantify disease course over one year.
Main Methods:
- Combining multiple individual assessments.
- Utilizing several validated scales and tests.
- Focusing on evaluation tools that are easy to handle and time-efficient.
Main Results:
- A protocol has been designed for multicenter Alzheimer's disease trials.
- The protocol allows for selection of homogeneous patient groups.
- It enables quantification of Alzheimer's disease progression over a one-year period.
Conclusions:
- The proposed protocol is suitable for multicenter studies.
- Challenges remain in evaluating therapeutic benefits due to incomplete knowledge of disease natural history and prognostic factors.