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Radiotherapy of relapse-refractory follicular lymphoma
É Grignano1, B Deau-Fischer2, G Loganadane1
1Department of radiation oncology, institut Curie, 26, rue d'Ulm, 75005 Paris, France.
Summary
External beam radiotherapy is effective for relapsed or refractory follicular lymphoma, achieving high remission rates. Further randomized studies are needed to confirm this treatment strategy.
Area of Science:
- Oncology
- Radiation Oncology
- Hematology
Background:
- Follicular lymphoma is an indolent non-Hodgkin lymphoma.
- Relapsed or refractory disease presents treatment challenges.
Purpose of the Study:
- To evaluate the efficacy and outcomes of external beam radiotherapy (EBRT) in patients with relapsed or refractory follicular lymphoma.
Main Methods:
- A study of 15 patients with relapsed/refractory follicular lymphoma treated with EBRT.
- Patients received a median dose of 30Gy in 15 fractions.
- Follow-up duration was a median of 61.9 months.
Main Results:
- Complete response (73%) and partial response (13%) were observed post-EBRT.
- Disease control was achieved in 66% after one or two EBRT courses.
- 86% of patients achieved remission at last follow-up, including those receiving salvage chemotherapy.
Conclusions:
- External beam radiotherapy is an effective treatment modality for relapsed/refractory follicular lymphoma when part of a multimodality approach.
- A Follicular Lymphoma International Prognostic Index (FLIPI) score >2 predicted non-control disease.
- Randomized trials are recommended to validate EBRT's role.
