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Perforation in Submucous Cleft Palate Due to Methotrexate-Induced Mucositis in a Patient With Rheumatoid Arthritis

Jung Woo Nam1

  • 1Department of Oral and Maxillofacial Surgery, Yonsei University College of Dentistry, Seoul, South Korea Department of Oral and Maxillofacial Surgery, Wonkwang University Sanbon Hospital, Gunpo-si, Republic of Korea.

The Journal of Craniofacial Surgery
|February 27, 2018
PubMed

Insights

Methotrexate (MTX) can cause severe oral mucositis, leading to palatal perforation in patients with undiagnosed submucous cleft palate (SMCP). Early recognition and MTX discontinuation are crucial for healing and surgical repair.

Area of Science:

  • Oral and Maxillofacial Surgery
  • Rheumatology
  • Pharmacology

Background:

  • Spontaneous palatal perforation is rare, with causes including tumors, trauma, and infection.
  • Methotrexate (MTX) is increasingly used for rheumatoid arthritis, carrying risks of oral complications like mucositis.

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