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TNFAIP3 mRNA Level Is Associated with Psychological Anxiety in Major Depressive Disorder

Ruei-An Chen1, Tiao-Lai Huang1, Kai-Wei Huang1,2

  • 1Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.

Neuroimmunomodulation
|February 28, 2018
PubMed
Abstract

Insights

Major depressive disorder (MDD) is linked to inflammation. This study found that only psychological anxiety symptoms in MDD patients correlated with TNFAIP3 mRNA expression levels.

Area of Science:

  • Neuroscience
  • Immunology
  • Genetics

Background:

  • Major depressive disorder (MDD) is associated with inflammation and immune dysregulation.
  • Previous research indicated an inverse correlation between depression severity and TNFAIP3 mRNA expression.
  • This study investigated the link between TNFAIP3 mRNA levels and specific MDD symptoms.

Purpose of the Study:

  • To evaluate the association between TNFAIP3 mRNA expression levels and symptoms of major depressive disorder (MDD).
  • To determine which specific symptoms of MDD correlate with TNFAIP3 mRNA expression.

Main Methods:

  • The study included 91 patients diagnosed with MDD (20 men, 71 women).
  • TNFAIP3 mRNA expression levels were measured.
  • Multiple linear regression analysis was used to assess relationships between HAMD-17 subscores and TNFAIP3 mRNA levels.

Main Results:

  • A significant correlation was found only between psychological anxiety subscores on the Hamilton Depression Rating Scale (HAMD-17) and TNFAIP3 mRNA expression.
  • Depressed mood, insomnia, work/activity impairment, and suicidal ideation did not show significant associations with TNFAIP3 mRNA levels.

Conclusions:

  • The findings suggest a specific association between psychological anxiety and TNFAIP3 mRNA levels in individuals with MDD.
  • TNFAIP3 mRNA may play a role in the manifestation of anxiety symptoms within the context of major depressive disorder.
Keywords:
AnxietyInflammationInnate immunityMajor depressive disorderTNFAIP3

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