Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Tree of Life - Bacteria, Archaea, Eukaryotes02:40

The Tree of Life - Bacteria, Archaea, Eukaryotes

39.3K
The “tree of life” describes the evolution of life and the evolutionary relationships between organisms. The root of the tree is the common ancestor to all life on Earth. All other species radiate from this point, much like the branches of a tree. The numerous tips of these branches on the tree of life represent every living, or extant, species. Extinct species, which are species that no longer exist, can be found towards the center of the tree. Currently, these organisms, both...
39.3K
Characteristics of Life01:23

Characteristics of Life

263.2K
Biology is a natural science that studies life and living organisms, including their structure, function, development, interactions, evolution, distribution, and taxonomy. The field's scope is extensive and divided into several specialized disciplines, such as anatomy, physiology, ethology, genetics, and many more. All living things share a few key traits, including cellular organization, heritable genetic material and the ability to adapt/evolve, metabolism to regulate energy needs, the...
263.2K
Half-life of a Reaction02:42

Half-life of a Reaction

39.4K
The half-life of a reaction (t1/2) is the time required for one-half of a given amount of reactant to be consumed. In each succeeding half-life, half of the remaining concentration of the reactant is consumed. For example, during the decomposition of hydrogen peroxide, during the first half-life (from 0.00 hours to 6.00 hours), the concentration of H2O2 decreases from 1.000 M to 0.500 M. During the second half-life (from 6.00 hours to 12.00 hours), the concentration decreases from 0.500 M to...
39.4K
The Angiosperm Life Cycle02:39

The Angiosperm Life Cycle

73.1K
Plants have a life cycle split between two multicellular stages: a haploid stage—with cells containing one set of chromosomes—and a diploid stage—with cells containing two sets of chromosomes. The haploid stage is the gamete-producing gametophyte, and the diploid stage is the spore-producing sporophyte.
73.1K
Life Tables01:22

Life Tables

550
A life table is a statistical tool that summarizes the mortality and survival patterns of a population, providing detailed insights into the likelihood of survival or death across different age intervals within a cohort. By organizing data on survival probabilities and mortality rates, life tables offer a clear snapshot of population dynamics over time. They are extensively used in demography, public health, actuarial science, and ecology to analyze life expectancy, design health interventions,...
550
Life Histories01:29

Life Histories

22.9K
Overview
22.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Methylation clocks for evaluation of anti-aging interventions.

Aging·2025
Same author

Biological Clocks: Why We Need Them, Why We Cannot Trust Them, How They Might Be Improved.

Biochemistry. Biokhimiia·2024
Same author

A laboratory and simulation platform to integrate individual life history traits and population dynamics.

Nature computational science·2023
Same author

How does the body know how old it is?

Experimental gerontology·2023
Same author

A Clinical Trial Using Methylation Age to Evaluate Current Antiaging Practices.

Rejuvenation research·2018
Same author

Questioning the inevitability of aging.

Proceedings of the National Academy of Sciences of the United States of America·2018

Related Experiment Video

Updated: Feb 13, 2026

Barnes Maze Testing Strategies with Small and Large Rodent Models
12:59

Barnes Maze Testing Strategies with Small and Large Rodent Models

Published on: February 26, 2014

43.9K

Combining Life Extension Treatments: A Proposal for High-Throughput Testing in Rodents.

Josh Mitteldorf1

  • 1Washington University School of Medicine, St. Louis, MO, USA. aging.advice@gmail.com.

Biochemistry. Biokhimiia
|March 1, 2018
PubMed
Summary

This study proposes novel experimental designs for efficiently screening combined interventions to extend lifespan in rodents. The methods prioritize identifying high-impact treatment combinations for future research, accelerating drug discovery.

More Related Videos

Detection of miRNA Targets in High-throughput Using the 3'LIFE Assay
12:49

Detection of miRNA Targets in High-throughput Using the 3'LIFE Assay

Published on: May 25, 2015

10.5K
Author Spotlight: Impact of Physical Barriers on Rodent Populations in Farmland Areas
03:29

Author Spotlight: Impact of Physical Barriers on Rodent Populations in Farmland Areas

Published on: March 8, 2024

995

Related Experiment Videos

Last Updated: Feb 13, 2026

Barnes Maze Testing Strategies with Small and Large Rodent Models
12:59

Barnes Maze Testing Strategies with Small and Large Rodent Models

Published on: February 26, 2014

43.9K
Detection of miRNA Targets in High-throughput Using the 3'LIFE Assay
12:49

Detection of miRNA Targets in High-throughput Using the 3'LIFE Assay

Published on: May 25, 2015

10.5K
Author Spotlight: Impact of Physical Barriers on Rodent Populations in Farmland Areas
03:29

Author Spotlight: Impact of Physical Barriers on Rodent Populations in Farmland Areas

Published on: March 8, 2024

995

Area of Science:

  • Gerontology and aging research
  • Experimental design and statistical modeling
  • Pharmacology and drug discovery

Background:

  • A significant backlog of potential life-extending treatments awaits mammalian testing.
  • Existing therapies are rarely evaluated in combination, despite nonlinear dose-response and interaction effects.
  • Optimized experimental designs are needed for high-throughput screening of complex interventions.

Purpose of the Study:

  • To propose and evaluate two experimental designs for high-throughput screening of combined interventions.
  • To maximize information gain for identifying synergistic treatments that extend lifespan.
  • To develop cost-effective protocols for prioritizing promising therapeutic combinations.

Main Methods:

  • Part I: Numerical simulations explored a protocol for single intervention dose-response assessment, maximizing information with unique dosages per animal.
  • Part II: Simulations evaluated a protocol for testing interactions among multiple treatment combinations (focusing on triplets).
  • Statistical inference using stepwise regression to identify individual treatment effects and pairwise interactions.

Main Results:

  • Single intervention testing is most informative when each animal receives a distinct dosage.
  • Testing combinations of three treatments offers a statistical sweet spot for detecting interactions.
  • The proposed protocol can detect lifespan extension greater than 50% with 80% certainty, conserving resources by not detailing all survival curves.

Conclusions:

  • The developed screening protocols can expedite the identification of potent life-extending treatment combinations.
  • These methods enable efficient prioritization of interventions with the largest potential impact on lifespan.
  • The designs balance statistical robustness with cost-effectiveness in preclinical aging research.