Related Experiment Video
Updated: Feb 3, 2026
09:09
In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
2.3K
A Clinical Trial Using Methylation Age to Evaluate Current Antiaging Practices.
11 School of Medicine, Washington University in St Louis, St Louis, Missouri.
Rejuvenation Research
|October 23, 2018
Summary
New DNA methylation clocks enable faster testing of anti-aging interventions. This study tracks 5000 individuals over two years to find lifestyle combinations that significantly slow biological aging.
Area of Science:
- Biogerontology
- Epigenetics
- Clinical Trials
Background:
- Advances in DNA methylation technology allow for precise measurement of biological aging.
- This breakthrough enables more efficient and cost-effective testing of anti-aging interventions.
- Current anti-aging strategies are widely adopted by the public but lack rigorous scientific validation.
Purpose of the Study:
- To clinically evaluate popular anti-aging strategies employed by health-conscious individuals.
- To identify synergistic combinations of lifestyle interventions that may retard the rate of aging.
- To develop a specialized methylation clock optimized for tracking individual aging trajectories.
Main Methods:
- Recruitment of 5000 participants aged 45-65 for a 2-year clinical trial.
- Detailed interviews on diet, exercise, supplements, and social practices influencing aging.
- Collection of blood samples at baseline, midpoint, and end for methylation age analysis.
Main Results:
- The primary endpoint is the change in methylation age over the 2-year study period.
- Exploratory analysis aims to detect synergistic effects of combined anti-aging strategies.
- A mock analysis confirmed the study's power to detect significant age retardation effects (≥25%).
Conclusions:
- This study will provide valuable insights into the efficacy of popular anti-aging interventions.
- Identifying synergistic lifestyle combinations could offer novel approaches to healthy aging.
- Open-sourced data will facilitate further research and public understanding of aging processes.
More Related Videos
04:53A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
Published on: September 20, 2019
11.3K
05:16Characterizing Exon Skipping Efficiency in DMD Patient Samples in Clinical Trials of Antisense Oligonucleotides
Published on: May 7, 2020
7.3K
Related Concept Videos
01:16Clinical Trials
10.5K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
There are four phases in a clinical trial. A phase one...
10.5K
01:11Clinical Trials: Overview
5.0K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
5.0K
01:12Statistical Software for Data Analysis and Clinical Trials
1.5K
Statistical software is pivotal in data analysis and clinical trials by providing tools to analyze data, draw conclusions, and make predictions. These software packages range from simple data management applications to complex analytical platforms, supporting various statistical tests, models, and simulation techniques. Their significance lies in their ability to handle vast amounts of data with precision and efficiency, enabling researchers to validate hypotheses, identify trends, and make...
1.5K
01:12Trial and Error and Algorithm
420
A problem-solving strategy is a plan of action used to find a solution. Different strategies have distinct action plans. Trial and error involves trying different solutions until one works. For instance, to fix a broken printer, you might check ink levels, ensure the paper tray isn't jammed, and verify the printer's connection to your laptop. This method can be time-consuming but is commonly used. Thomas Edison, for example, used trial and error to find a suitable filament for the light...
420
01:30Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
783
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
783
01:21Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
438
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
438