Related Experiment Video
Updated: Feb 13, 2026

Neuronavigation and Laparoscopy Guided Ventriculoperitoneal Shunt Insertion for the Treatment of Hydrocephalus
Published on: October 14, 2022
Is There a Link Between ICP-Derived Infusion Test Parameters and Outcome After Shunting in Normal Pressure
Eva Nabbanja1, Marek Czosnyka2, Nicole C Keong3
1Division of Neurosurgery, Cambridge University Hospital, Cambridge, UK.
Objective:
The term "hydrocephalus" encompasses a range of disorders characterised by clinical symptoms, abnormal brain imaging and derangement of cerebrospinal fluid (CSF) dynamics. The ability to elucidate which patients would benefit from CSF diversion (a shunt or third ventriculostomy) is often unclear. Similar difficulties are encountered in shunted patients to predict the scope for improvement by shunt re-adjustment or revision.
Materials And Methods:
We compared retrospective pre-shunting infusion test results performed in 310 adult patients diagnosed with normal pressure hydrocephalus (NPH) and their improvement after shunting.
Results:
Resistance to CSF outflow correlated significantly with improvement (p < 0.05). Other markers known from the literature, such as amplitude in CSF pulse pressure, the slope of the amplitude-pressure regression line, or elasticity did not show any correlation with outcome.
Conclusion:
Outcome following shunting in adult NPH is associated with resistance to CSF outflow; however, the latter cannot be taken as an absolute predictor of shunt response.
More Related Videos
Related Concept Videos
Shunt Admittances
To model this effect, the method of images is employed. This method involves replacing the Earth with an image conductor that mirrors the original...
Covalently Linked Protein Regulators
These groups modify specific amino acids in a protein....
Predicting Reaction Outcomes
Vapor Pressure
Outcomes of Glycolysis
Cellular respiration can occur aerobically (with oxygen) or anaerobically (without oxygen). In the presence of oxygen, cellular respiration starts with glycolysis and continues with pyruvate...
Normal Distribution

