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Cerebrospinal Fluid and Cerebral Blood Flows in Idiopathic Intracranial Hypertension

Cyrille Capel1,2,3, Marc Baroncini4, Catherine Gondry-Jouet5

  • 1Neurosurgery Department, Hospital University Center of Amiens-Picardie, Amiens, France. capel.cyrille@chu-amiens.fr.

Acta Neurochirurgica. Supplement
|March 2, 2018
PubMed

Insights

Idiopathic intracranial hypertension (IIH) is linked to increased cerebrospinal fluid (CSF) and arteriovenous flow. This study found higher CSF and vascular flow in IIH patients, suggesting a hydrodynamic disturbance.

Area of Science:

  • Neurology
  • Neurosurgery
  • Radiology

Background:

  • Cerebrospinal fluid (CSF) and blood flow dynamics are closely related during the cardiac cycle.
  • Idiopathic intracranial hypertension (IIH) is suspected to involve hemodynamic and hydrodynamic disturbances.

Purpose of the Study:

  • To investigate the interaction between CSF and blood flow in patients with IIH.
  • To analyze cerebral hydrodynamic and hemodynamic parameters in IIH.

Main Methods:

  • Retrospective analysis of phase-contrast MRI (PCMRI) data.
  • Inclusion of 13 IIH patients and 16 control subjects.
  • Measurement of arterial and venous flow parameters, arteriovenous flow, and CSF flow (peak flow and stroke volume).

Main Results:

  • No significant differences were observed in arterial and venous flow parameters between IIH and control groups.
  • IIH patients exhibited significantly higher arteriovenous peak flow (PFav) and vascular stroke volume (SVVASC).
  • Cerebrospinal fluid peak flow (PFCSF) and stroke volume (SVCSF) were significantly elevated in the IIH group.

Conclusions:

  • Despite normal arterial and venous flow, increased arteriovenous flow and CSF flow were detected in IIH.
  • A potential phase shift in venous outflow may contribute to increased arteriovenous pulsatility and brain expansion.
  • Elevated arteriovenous flow may lead to increased CSF displacement and intracranial pressure (ICP) in IIH.
Abstract

Keywords:
Cerebral hemodynamicCerebral hydrodynamicIntracranial hypertensionPhase-contrast MRI

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