Diversity of hysteresis in a fully cooperative coinfection model
Jorge P Rodríguez1, Yu-Hao Liang2, Yu-Jhe Huang2
1Instituto de Física Interdisciplinary Sistemas Complejos IFISC (CSIC-UIB), 07122 Palma de Mallorca, Spain.
Abstract:
We propose a fully cooperative coinfection model in which singly infected individuals are more likely to acquire a second disease than susceptible ones and doubly infected individuals are also assumed to be more contagious than singly infected ones. The dynamics of such a fully cooperative coinfection model is investigated through the well-mixed approach. In particular, discontinuous outbreak transitions from the disease free state or the low prevalence state to the high prevalence state can be separately observed as a disease transmission rate crosses a threshold αo from the below when the epidemic is still in the early stages. Moreover, discontinuous eradications from the high prevalence state to the low prevalence or disease free state are also separately seen as the transmission rate reaches a threshold αe(<αo) from the above when the outbreak occurs. Such phenomena constitute three types of hysteresis, where only one type has been identified before. Complete characterization of these three types of hysteresis in terms of parameters measuring the uniformity of the model is both analytically and numerically provided.
Related Concept Videos
Cooperative Allosteric Transitions
Cooperative Allosteric Transitions
Cooperative Allosteric Transitions
Cooperative Binding of Transcription Regulators
Cooperative Binding of Transcription Regulators
Cell Diversity
Multicellular...


