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Cancer02:18

Cancer

54.6K
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
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What is Cancer?02:12

What is Cancer?

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Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of...
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Cancer Prevention02:59

Cancer Prevention

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Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
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Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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Cancer Vaccines01:30

Cancer Vaccines

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Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
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Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Related Experiment Video

Updated: Feb 13, 2026

Orthotopic Mouse Model of Colorectal Cancer
08:43

Orthotopic Mouse Model of Colorectal Cancer

Published on: December 4, 2007

47.2K

Colorectal Cancer:: Imaging Conundrums.

Nathan C Hall1, Alexander T Ruutiainen2

  • 1Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA; Diagnostic Imaging, Nuclear Medicine, Corporal Michael J. Crescenz VA Medical Center, 3900 Woodland Avenue, Philadelphia, PA 19104, USA; Department of Surgery, Division of Surgical Oncology, The Ohio State University Wexner Medical Center, 410 West 10th Avenue, Columbus, OH 43210, USA.

Surgical Oncology Clinics of North America
|March 3, 2018
PubMed
Summary

Advanced imaging detects small colorectal cancer metastases, but survival gains are limited. Real-time operative guidance could resolve imaging conundrums and enable fluorodeoxyglucose PET/CT staging.

Keywords:
Colorectal cancerComputed tomographyLiverLymph nodesMetastasesPETSurgeryTNM staging

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Orthotopic Implantation of Patient-Derived Cancer Cells in Mice Recapitulates Advanced Colorectal Cancer

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Related Experiment Videos

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Orthotopic Implantation of Patient-Derived Cancer Cells in Mice Recapitulates Advanced Colorectal Cancer

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Area of Science:

  • Oncology
  • Medical Imaging
  • Surgical Technology

Background:

  • Technological advancements in imaging have increased preoperative detection of small colorectal cancer metastases.
  • Despite improved detection, patient survival rates have not shown corresponding linear gains.
  • Current imaging may lead to false-positive upstaging in some colorectal cancer cases.

Purpose of the Study:

  • To address the conundrums in colorectal cancer imaging, specifically the gap between detection sensitivity and survival outcomes.
  • To explore the potential of real-time imaging guidance during surgery to improve colorectal cancer management.
  • To evaluate the feasibility of using fluorodeoxyglucose PET/CT for initial staging of colorectal cancer.

Main Methods:

  • Review of current imaging technologies for colorectal cancer detection.
  • Analysis of the impact of advanced imaging on patient survival and staging accuracy.
  • Conceptual proposal for integrating real-time intraoperative imaging guidance.
  • Discussion of the role of fluorodeoxyglucose PET/CT in staging.

Main Results:

  • Preoperative imaging sensitivity for small colorectal cancer foci has improved.
  • A disconnect exists between enhanced imaging detection and patient survival benefits.
  • Potential for false-positive upstaging due to current imaging limitations.
  • Real-time imaging guidance is proposed as a solution to current imaging challenges.

Conclusions:

  • Real-time imaging guidance during surgery may resolve key conundrums in colorectal cancer detection and staging.
  • Widespread adoption of such guidance could facilitate the use of fluorodeoxyglucose PET/CT for initial colorectal cancer staging.
  • Integrating advanced imaging techniques intraoperatively holds promise for improving patient outcomes.