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Neurological deficit is predicted by S100B in children after cardiac surgery

O Bar-Yosef1, D Greidinger2, M Iskilova3

  • 1Pediatric Neurology Unit and Talpiot Medical Leadership Program, Edmond and Lili Safra Children's Hospital, Chaim Sheba Medical Center affiliated with the Sackler School of Medicine, Tel-Aviv University, Ramat Gan 5262100, Israel; Edmond and Lili Safra Children's Hospital, Tel-Aviv University, Ramat Gan 5262100, Israel; Chaim Sheba Medical Center affiliated with Sackler School of Medicine, Tel-Aviv University, Ramat Gan, Israel.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|March 3, 2018
PubMed

Insights

Serum S100B effectively identifies brain injuries in children post-cardiac surgery. Elevated S100B levels detected early can aid in timely interventions for new neurological deficits.

Area of Science:

  • Biomarkers
  • Pediatric Neurology
  • Cardiac Surgery

Background:

  • Children undergoing cardiac surgery are at risk for post-operative brain injuries and neurological deficits.
  • Early detection of these injuries is crucial for timely therapeutic interventions.
  • The study investigates S100B as a potential biomarker for detecting such injuries.

Purpose of the Study:

  • To evaluate the efficacy of S100B as an early biomarker for brain injury following pediatric cardiac surgery.
  • To determine if S100B levels correlate with the development of new neurological deficits (NND).

Main Methods:

  • Seventy-five pediatric patients undergoing cardiac surgery were enrolled.
  • Serum S100B levels were measured pre-operatively and at 6, 12, and 24 hours post-surgery.
  • Neurological assessments were performed using the Pediatric Stroke Outcome Measure (PSOM) to define NND.

Main Results:

  • Twenty patients developed new neurological deficits (NND) post-surgery.
  • Significantly higher S100B z-scores were observed in the NND group at all post-operative time points.
  • A S100B cut-off of 3 z-scores at 6 hours yielded a 79% positive and 90% negative predictive value for NND.

Conclusions:

  • S100B serves as a potent early biomarker for identifying brain injury after pediatric cardiac surgery.
  • Monitoring S100B levels may facilitate the prevention of neurological injury progression in this patient population.
Abstract

Keywords:
Brain injuryCongenital heart defectsNeurologyPediatric intensive care unitS100B

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