A strategy for systemic toxicity assessment based on non-animal approaches: The Cosmetics Europe Long Range Science...

Area of Science:

• Toxicology
• Risk Assessment
• Chemical Safety

Background:

• Non-animal approaches for chemical systemic toxicity assessment are challenging.
• The SEURAT-1 program (2011-2015) highlighted the need for improved toxicokinetic and toxicodynamic tools.
• Existing tools like TTCs and read-across require further implementation for safety assessments.

Purpose of the Study:

• To present a tiered scientific workflow for chemical safety assessment.
• To implement the workflow developed from SEURAT-1 outcomes.
• To address the evaluation of internal dose in systemic exposure scenarios.

Main Methods:

• A tiered scientific workflow addressing the four steps of the risk assessment paradigm.
• Implementation of the workflow through the Cosmetics Europe Long Range Science Strategy (LRSS) program (2016-2020).
• Focus on evaluating internal dose for systemic exposure.

Main Results:

• A structured workflow for non-animal safety assessment has been established.
• The workflow integrates toxicokinetic and toxicodynamic considerations.
• Case studies will demonstrate the workflow's applicability.

Conclusions:

• The LRSS program provides a framework for non-animal safety evaluation.
• The workflow is applicable to cosmetic chemicals and broadly to any chemical.
• Further research and tool development are crucial for advancing non-animal safety testing.