Exploring the sortilin related receptor, SorLA, in depression
Henriette N Buttenschøn1, Betina Elfving2, Marit Nielsen2
1Translational Neuropsychiatry Unit, Department of Clinical Medicine, Aarhus University, Denmark; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark.
Journal of Affective Disorders
|March 3, 2018
Summary
Serum SorLA levels may aid in depression diagnosis when combined with other factors. While not a standalone biomarker, SorLA levels increased with nortriptyline treatment in depressed individuals.
Area of Science:
- Neuroscience
- Biochemistry
- Psychiatry
Background:
- Individual depression biomarkers lack clinical sensitivity and specificity.
- The sorting-related receptor with A-type repeats (SorLA) is linked to Alzheimer's and neurological disorders.
- The SORCS3 gene is associated with depression, and sortilin levels are reduced in depressed individuals.
Purpose of the Study:
- To investigate the role of serum SorLA levels in depression.
- To determine if SorLA can serve as a biomarker for depression diagnosis or treatment response.
Main Methods:
- Serum SorLA levels were measured using ELISA in two clinical samples.
- Generalized linear models were employed for statistical analysis.
- Multivariate models were developed to discriminate between depressed individuals and healthy controls.
Main Results:
- A multivariate model including serum SorLA, previous depressive episodes, stressful life events, sortilin, and VEGF differentiated depressed individuals from controls.
- No significant difference in SorLA levels was found between depressed individuals and healthy controls as an isolated factor.
- Serum SorLA levels significantly increased after 12 weeks of nortriptyline treatment, but not escitalopram.
Conclusions:
- SorLA, in combination with other factors, may support depression diagnosis.
- SorLA is not a reliable individual biomarker for depression.
- SorLA is not indicative of treatment response to escitalopram but may be influenced by nortriptyline.
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