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The use of selective estrogen receptor modulators on bone health in men

Sok Kuan Wong¹, Nur-Vaizura Mohamad¹, Putri Ayu Jayusman¹

¹a Department of Pharmacology, Faculty of Medicine , Universiti Kebangsaan Malaysia , Cheras , Kuala Lumpur , Malaysia.

The Aging Male : the Official Journal of the International Society for the Study of the Aging Male

|March 7, 2018

Abstract:

Selective estrogen receptor modulators (SERMs) represent a class of drugs that act as agonist or antagonist for estrogen receptor in a tissue-specific manner. The SERMs drugs are initially used for the prevention and treatment of osteoporosis in postmenopausal women. Bone health in prostate cancer patients has become a significant concern, whereby patients undergo androgen deprivation therapy is often associated with deleterious effects on bone. Previous preclinical and epidemiological findings showed that estrogens play a dominant role in improving bone health as compared to testosterone in men. Therefore, this evidence-based review aims to assess the available evidence derived from animal and human studies on the effects of SERMs on the male skeletal system. The effects of SERMs on bone mineral density (BMD)/content (BMC), bone histomorphometry, bone turnover, bone strength and fracture risk have been summarized in this review.

Keywords:

Osteoporosis lasofoxifene raloxifene tamoxifen toremifene

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