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Bactericidal and Hemocompatible Coating via the Mixed-Charged Copolymer.

Xiao-Li Fan1, Mi Hu1, Zhi-Hui Qin1

  • 1MOE Key Laboratory of Macromolecule Synthesis and Functionalization, Department of Polymer Science and Engineering , Zhejiang University , Hangzhou 310027 , China.

ACS Applied Materials & Interfaces
|March 7, 2018
PubMed
Summary

This study developed a novel mixed-charged copolymer coating that combines antibacterial properties with improved hemocompatibility for medical devices. The new coating enhances blood compatibility while maintaining effective bacterial resistance.

Keywords:
antibacterial coatingcontact killing of bacteriaimproved hemocompatibilitymixed-charged copolymerpyridinequaternary ammonium compoundsultrasonic spraying

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Surface Engineering

Background:

  • Cationic antibacterial coatings using quaternary ammonium compounds offer broad-spectrum bactericidal properties.
  • High positive charge density in these coatings often leads to poor hemocompatibility, limiting their use in blood-contacting applications.
  • Negatively charged surfaces are known to reduce blood coagulation and improve hemocompatibility.

Purpose of the Study:

  • To develop a novel antibacterial coating with enhanced hemocompatibility for blood-contacting medical devices and implants.
  • To synthesize and characterize mixed-charged copolymers combining cationic and anionic groups.
  • To evaluate the antibacterial efficacy and hemocompatibility of the developed copolymer coatings.

Main Methods:

  • Synthesis of poly (quaternized vinyl pyridine- co- n-butyl methacrylate- co-methacrylate acid) [P(QVP- co- nBMA- co-MAA)] copolymers via free radical copolymerization.
  • Characterization of copolymer coating properties, including hydrophilicity and zeta potential, by varying the anionic/cationic ratio.
  • Assessment of antibacterial activity, coagulation time, platelet adhesion, and hemolysis to evaluate hemocompatibility.

Main Results:

  • Copolymer coatings exhibited increased hydrophilicity and a tunable zeta potential from positive to negative with increasing anionic content.
  • Antibacterial efficacy of the mixed-charged coatings remained comparable to pure cationic coatings.
  • Hemocompatibility significantly improved, evidenced by longer coagulation times, reduced platelet adhesion, and lower hemolysis rates with the addition of anionic groups.

Conclusions:

  • The developed mixed-charged copolymer coating successfully integrates potent bactericidal properties with superior hemocompatibility.
  • This innovative material demonstrates significant potential for applications in antibacterial blood-contacting devices and implants.
  • The strategy of combining cationic and anionic groups in copolymers offers a promising approach for advanced biomaterial design.