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Updated: Feb 13, 2026

A Novel Application of Musculoskeletal Ultrasound Imaging
Published on: September 17, 2013
[Homeostasis and Disorder of Musculoskeletal System.Cellular dynamics in musculoskeletal system visualized by
Junichi Kikuta1, Masaru Ishii1
1Department of Immunology and Cell Biology, Graduate School of Medicine and Frontier Biosciences, Osaka University, Japan.
Abstract:
Bone is continually remodeled by bone-resorbing osteoclasts and bone-forming osteoblasts. Although it has long been believed that bone homeostasis is tightly regulated by communication between osteoclasts and osteoblasts, the fundamental process and dynamics have remained elusive. We originally established an advanced imaging system to visualize living bone tissues using intravital two-photon microscopy. By means of this system, we revealed the in vivo behavior of bone-resorbing osteoclasts and bone-forming osteoblasts in bone tissues. This approach facilitates investigation of cellular dynamics in the pathogenesis of musculoskeletal disorders, and would thus be useful for evaluating the efficacy of novel therapeutic agents.
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