Primary hepatic marginal zone lymphoma: A rare coincidence

Area of Science:

• Hepatology
• Oncology
• Hematology

Background:

• Primary hepatic lymphoma (PHL) is an exceedingly rare malignancy.
• Optimal therapeutic strategies and patient outcomes for PHL remain uncertain.
• Mucosa-associated lymphoid tissue (MALT) type PHL represents an even rarer subtype.

Observation:

• This report details a rare case of an elderly female diagnosed with PHL of the MALT type.
• Initial treatment with single-agent rituximab led to disease progression after 18 months.
• The patient subsequently developed Waldenström's macroglobulinemia concurrently.

Findings:

• The patient received two cycles of the RCOP regimen (rituximab, cyclophosphamide, vincristine, prednisone).
• Current patient status is stable following RCOP treatment.
• This case underscores the diagnostic challenges and rarity of PHL, particularly the MALT subtype.

Implications:

• Accurate and timely diagnosis of PHL is crucial for effective treatment initiation.
• The case emphasizes the need for meticulous pathological examination for rare liver malignancies.
• Further research into optimal treatment protocols for rare PHL subtypes is warranted.