Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Life events, depressive symptoms, and immune function.

M Irwin, M Daniels, E T Bloom

    The American Journal of Psychiatry
    |April 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    70&#x2003;Glycolytic substrates influence intracellular movement of <i>PKM2</i> and <i>OCT4</i> expression in bovine preimplantation embryos.

    Reproduction, fertility, and development·2022
    Same author

    Pro-inflammatory activation of microglia in the brain of patients with sepsis.

    Neuropathology and applied neurobiology·2018
    Same author

    Low testosterone is associated with disability in men with multiple sclerosis.

    Multiple sclerosis (Houndmills, Basingstoke, England)·2014
    Same author

    Inter- and intracellular distribution of amino acids and other metabolites in maize (Zea mays L.) leaves.

    Planta·2013
    Same author

    MRI characterization and longitudinal study of focal cerebellar lesions in a young tuberous sclerosis cohort.

    AJNR. American journal of neuroradiology·2012
    Same author

    Immunogenicity and efficacy of a DNA vaccine in aged mice.

    The journals of gerontology. Series A, Biological sciences and medical sciences·2008
    Same journal

    Global Prevalence of Obsessive-Compulsive and Related Disorders: A Systematic Review and Modeling Study.

    The American journal of psychiatry·2026
    Same journal

    Treatment Patterns and Barriers to Care Among U.S. Adults With Co-Occurring Substance Use Disorder and Mental Illness.

    The American journal of psychiatry·2026
    Same journal

    Implantable Neuromodulation Devices in Psychiatry: Human Fidelity and Implementation Challenges.

    The American journal of psychiatry·2026
    Same journal

    Convergent Network Localization of Brain Stimulation Targets for Trait Anxiety.

    The American journal of psychiatry·2026
    Same journal

    2026 Annual Meeting: President-Elect Address.

    The American journal of psychiatry·2026
    Same journal

    2026 Annual Meeting: CEO and Medical Director's Address.

    The American journal of psychiatry·2026
    See all related articles

    Major life events and depression impair immune function. Stressful changes reduced natural killer (NK) cell activity, while depressive symptoms affected NK cells and T cell balance.

    Area of Science:

    • Psychoneuroimmunology
    • Immunology
    • Stress and Health

    Background:

    • Bereavement and depression are linked to weakened immune responses.
    • Life events can significantly impact psychological and physiological well-being.
    • Understanding immune changes associated with stress is crucial for mental health research.

    Purpose of the Study:

    • To investigate the relationship between the magnitude of recent life events and immune function indicators.
    • To examine how depressive symptoms correlate with specific immune cell measures.

    Main Methods:

    • Studied 37 women with varying levels of recent life events.
    • Assessed natural killer (NK) cell activity.
    • Measured T cell subpopulations, including T helper and T suppressor/cytotoxic cells.

    Related Experiment Videos

    Main Results:

    • Women experiencing major life changes exhibited lower NK cell activity compared to those with fewer changes.
    • Increased severity of depressive symptoms correlated with impaired NK cell activity.
    • Depression was associated with a loss of suppressor/cytotoxic cells and an elevated T helper to T suppressor/cytotoxic cell ratio.

    Conclusions:

    • Significant life events and depressive symptoms can negatively impact crucial immune functions.
    • Immune system alterations, including NK cell activity and T cell balance, are sensitive to psychological stress.
    • Findings highlight the interconnectedness of psychological state and immune health.