Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Contact Angle01:13

Contact Angle

25.7K
When a solid is dipped inside a liquid, the liquid surface becomes curved near the contact. For some solid–liquid interfaces, the liquid is pulled up along the solid, while for others, the liquid surface is convex or depressed near the solid surface. This phenomenon can be explained using the concept of cohesive and adhesive forces.
The adhesive force is the molecular force between molecules of different materials, that is, between the molecules of the solid and the liquid. The cohesive...
25.7K
Contact-dependent Signaling01:19

Contact-dependent Signaling

47.6K
Contact-dependent signaling, as the name suggests, requires that communicating cells be in direct contact with each other. This is achieved either through receptor-ligand interactions or by specialized cytoplasmic channels that allow the flow of small molecules between cells. In animal cells, channels called gap junctions facilitate contact-dependent signaling in certain tissues, whereas, plasmodesmata perform a similar function in plants.
Gap Junctions
In animal cells, gap junctions are formed...
47.6K
Transmission-based Precautions I: Contact, Enteric, and Droplets01:17

Transmission-based Precautions I: Contact, Enteric, and Droplets

4.7K
Transmission-based precautions are for patients known to be infected or suspected to be infected or colonized with organisms that pose a significant risk to others. Some transmission-based precautions include contact, enteric, and droplet.
Contact Precautions:
Contact precautions are the measures taken to prevent the transmission of infectious agents, especially epidemiologically important microorganisms such as MRSA or influenza, primarily transmitted through direct or indirect contact with an...
4.7K
Lattice Centering and Coordination Number02:33

Lattice Centering and Coordination Number

12.4K
The structure of a crystalline solid, whether a metal or not, is best described by considering its simplest repeating unit, which is referred to as its unit cell. The unit cell consists of lattice points that represent the locations of atoms or ions. The entire structure then consists of this unit cell repeating in three dimensions. The three different types of unit cells present in the cubic lattice are illustrated in Figure 1.
Types of Unit Cells
Imagine taking a large number of identical...
12.4K
Responses to Gravity and Touch02:26

Responses to Gravity and Touch

42.0K
Gravitropism: Plant Responses to Gravity
42.0K
Improving Translational Accuracy02:07

Improving Translational Accuracy

15.0K
Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
15.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Gold nanoparticles in skin drug delivery: a bibliometric analysis of research trends from 2015 to 2025.

Frontiers in medical technology·2026
Same author

Unidirectional Evaporation-Induced Tunable and Continuous Gradient Composite Structure for Absorption-Dominant Electromagnetic Interference Shielding.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Role of metal nanomaterials in wound healing - a review.

Frontiers in bioengineering and biotechnology·2026
Same author

Machine learning-augmented lateral flow assays for point-of-care infectious disease diagnostics.

Lab on a chip·2026
Same author

Development and kinetic evaluation of vitamin C-loaded contact lenses prepared by a simple soaking technique.

Frontiers in medical technology·2026
Same author

Sustainable Approaches to Treat Syneresis Using Bioengineered Ocular Models.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
Same journal

Sodium-Based Battery Component Design: Imitating Lithium or Forging New Paths?

Small (Weinheim an der Bergstrasse, Germany)·2026
Same journal

Enhancing Birefringence of Sulphates by Polarity Modification in Planar Cations.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same journal

In Situ Atomic-Scale Observation of Preferential Premelting at Oxide Crystal Defects.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same journal

Thickness-Dependent Semiconductor-Metal Transition in Two-Dimensional Nonlayered Magnetic CuCo<sub>2</sub>S<sub>4</sub>.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same journal

Programmable Control Over Radical and Non‑Radical Pathways in Fenton‑Like Catalysis via Carbon‑Encapsulated Iron Nanoreactors.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same journal

Self-Powered MXene@Perovskite Thermoelectric Skin for Multimodal Mid-Infrared Sensing and Human Signal Recognition.

Small (Weinheim an der Bergstrasse, Germany)·2026
See all related articles

Related Experiment Video

Updated: Feb 13, 2026

Development of an In Vitro Ocular Platform to Test Contact Lenses
08:28

Development of an In Vitro Ocular Platform to Test Contact Lenses

Published on: April 6, 2016

11.2K

Microfluidic Contact Lenses.

Nan Jiang1, Yunuen Montelongo2,3, Haider Butt4

  • 1School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, 02138, USA.

Small (Weinheim an Der Bergstrasse, Germany)
|March 10, 2018
PubMed
Summary
This summary is machine-generated.

Researchers developed a new method to create microfluidic contact lenses for point-of-care diagnostics. These smart contact lenses enable minimally invasive monitoring and drug delivery for ophthalmic conditions.

Keywords:
contact lensesdiagnosticslaser ablationmicrofluidicstear film

More Related Videos

Studies of Bacterial Chemotaxis Using Microfluidics - Interview
10:35

Studies of Bacterial Chemotaxis Using Microfluidics - Interview

Published on: May 28, 2007

8.7K
Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis
08:25

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis

Published on: September 26, 2022

3.5K

Related Experiment Videos

Last Updated: Feb 13, 2026

Development of an In Vitro Ocular Platform to Test Contact Lenses
08:28

Development of an In Vitro Ocular Platform to Test Contact Lenses

Published on: April 6, 2016

11.2K
Studies of Bacterial Chemotaxis Using Microfluidics - Interview
10:35

Studies of Bacterial Chemotaxis Using Microfluidics - Interview

Published on: May 28, 2007

8.7K
Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis
08:25

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis

Published on: September 26, 2022

3.5K

Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Ophthalmology

Background:

  • Contact lenses are widely used for vision correction and cosmetic purposes.
  • Sensing capabilities in contact lenses offer a promising avenue for minimally invasive point-of-care diagnostics.
  • Developing integrated microfluidic systems within contact lenses is crucial for advanced ophthalmic applications.

Purpose of the Study:

  • To develop a microlithography method for fabricating microconcavities and microchannels in hydrogel-based contact lenses.
  • To optimize parameters for controlled fabrication of microfluidic features.
  • To demonstrate the functionality of these microfluidic contact lenses for diagnostic and therapeutic applications.

Main Methods:

  • Utilized a combination of laser patterning and embedded templating for microfabrication.
  • Optimized optical microlithography parameters (ablation power, beam speed) to control microconcavity dimensions (100 µm depth, 1.5 mm diameter).
  • Employed fiber templating to create microchannels (100-150 µm diameter) and validated leak-proof connections using fluorescent microbeads in artificial tear fluid.

Main Results:

  • Successfully fabricated microconcavities and microchannels within hydrogel contact lenses.
  • Achieved precise control over microfeature dimensions through optimized laser parameters.
  • Demonstrated leak-proof integration of microfluidic components and optical excitation/emission capabilities using functionalized fluorophores.

Conclusions:

  • The developed microlithography technique enables the creation of functional microfluidic contact lenses.
  • These microfluidic contact lenses hold potential for point-of-care ophthalmic monitoring of metabolic disorders.
  • Potential applications include controlled drug delivery and advanced diagnostics in ophthalmology.