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Closed-loop Neuropharmacology for Epilepsy: Distant Dream or Future Reality?
Irene Aicua-Rapun1, Pascal André2, Jan Novy1
1Department of Clinical Neurosciences, University Hospital and Faculty of Biology and Medicine, Lausanne, Switzerland.
Current Neuropharmacology
|March 10, 2018
Summary
Epilepsy treatment relies on observation, but closed-loop therapy could improve seizure control. This review explores therapeutic drug monitoring, biomarkers for disease activity, and pharmacogenetics for personalized epilepsy management.
Area of Science:
- Neurology
- Pharmacology
- Biomarker Discovery
Background:
- Epilepsy is a common neurological disorder, with many patients achieving seizure freedom through medication.
- Current epilepsy treatment management is largely empirical and observational.
- Developing more efficient epilepsy treatment regimens is a significant clinical need.
Purpose of the Study:
- To review current practices and future developments in therapeutic drug monitoring for epilepsy.
- To explore potential biomarkers for monitoring epilepsy disease activity.
- To discuss the role of pharmacogenetics in optimizing epilepsy treatment.
Main Methods:
- Literature review of therapeutic drug monitoring in epilepsy.
- Analysis of potential biomarkers for epilepsy activity monitoring.
- Discussion of pharmacogenetic factors influencing epilepsy treatment response.
Main Results:
- Therapeutic drug monitoring (TDM) is crucial but requires further development for epilepsy.
- Biomarkers offer potential for objective monitoring of epilepsy disease activity.
- Pharmacogenetics can guide personalized drug selection and dosing in epilepsy.
Conclusions:
- Advancements in TDM, biomarker identification, and pharmacogenetics promise more precise and effective epilepsy management.
- Closed-loop therapeutic strategies could revolutionize epilepsy treatment efficiency.
- Personalized approaches are key to overcoming the empirical nature of current epilepsy care.
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