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Dual Effects of Melanoma Cell-derived Factors on Bone Marrow Adipocytes Differentiation
Published on: August 23, 2018
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Factors Related to Nevus-Associated Cutaneous Melanoma: A Case-Case Study
Nirmala Pandeya1, Marina Kvaskoff2, Catherine M Olsen1
1Population Health Department, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia; School of Public Health, The University of Queensland, Herston, Queensland, Australia.
The Journal of Investigative Dermatology
|March 11, 2018
Summary
Melanomas with nevus remnants (nevus-associated melanomas) are linked to younger age, specific mole counts, and BRAF mutations. These findings suggest a distinct origin pathway for nevus-associated melanomas compared to de novo melanomas.
Area of Science:
- Dermatology
- Oncology
- Pathology
Background:
- Cutaneous melanomas can arise from pre-existing nevi or de novo.
- Evidence suggests distinct molecular and epidemiological profiles for nevus-associated melanomas versus de novo melanomas.
Purpose of the Study:
- To investigate the molecular, host, and environmental factors associated with nevus remnants in cutaneous melanomas.
- To differentiate nevus-associated melanomas from de novo melanomas based on various characteristics.
Main Methods:
- A population-based study of 636 cutaneous melanomas.
- Dermatopathology review to identify neval remnants.
- Analysis of molecular, host, and environmental factors.
Main Results:
- Nevus-associated melanomas were associated with younger age, non-brown eyes, trunk site, thinness (<0.5 mm), and BRAFV600E mutation.
- Patients with nevus-associated melanomas reported more teenage moles and higher total nevus counts, but fewer facial freckles.
- Histologic examination showed less dermal elastosis in skin adjacent to nevus-associated melanomas.
Conclusions:
- Nevus-associated melanomas exhibit distinct clinical, host, and molecular features.
- These findings support a unique causal pathway for nevus-associated melanomas, differing from de novo melanomas.
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