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Updated: Feb 13, 2026

Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine
Published on: February 16, 2018
Carbon dioxide-based facile synthesis of cyclic carbamates from amino alcohols
Teemu Niemi1, Israel Fernández2, Bethany Steadman1
1Department of Chemistry, University of Helsinki, P.O. Box 55, 00014, Finland. timo.repo@helsinki.fi.
Abstract:
We report herein a straightforward general method for the synthesis of cyclic carbamates from amino alcohols and carbon dioxide in the presence of an external base and a hydroxyl group activating reagent. Utilizing p-toluenesulfonyl chloride (TsCl), the reaction proceeds under mild conditions, and the approach is fully applicable to the preparation of various high value-added 5- and 6-membered rings as well as bicyclic fused ring carbamates. DFT calculations and experimental results indicate a SN2-type reaction mechanism with high regio-, chemo-, and stereoselectivity.
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