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Published on: March 20, 2018
Potential antioxidant activity of Morita-Baylis-Hillman adducts
Haitham Elleuch1, Wafa Mihoubi2, Mohamed Mihoubi3
1Laboratoire de Chimie Organique Structurale LR99ES14, Faculté des Sciences de Tunis, Université de Tunis El Manar, Campus Universitaire, 2092 Tunis, Tunisia.
Abstract:
The wide variety of potent biological activities of Morita-Baylis-Hillman adducts (MBH) encouraged us to synthesize new series of products belonging to this class of compounds, possessing different functionalities and exhibiting potential antioxidant activity. As part of our on-going program on targeting molecules with antioxidant activity, we describe herein different DPPH (2,2-diphenyl-1-picrylhydrazyl) scavenging activities of MBH alcohols and their derivatives including acetates, phosphonates and hydrazonophosphonates. The obtained results showed that the strongest DPPH radical scavenging activity was observed in the case of hydrazonophosphonates in comparison to the other MBH derivatives.
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