Related Experiment Video
Updated: Feb 13, 2026

Quantitative Real-Time PCR using the Thermo Scientific Solaris qPCR Assay
Published on: June 17, 2010
Scientific progress despite irreproducibility: A seeming paradox
Richard M Shiffrin1, Katy Börner2, Stephen M Stigler3
1Department of Psychological and Brain Sciences, Indiana University Bloomington, Bloomington, IN 47405; shiffrin@indiana.edu.
Science rapidly advances yet faces reproducibility issues. This paradox is inherent to scientific progress and requires selective improvements, not stifling innovation, to ensure continued societal benefits.
Area of Science:
- Metascience
- Philosophy of Science
- Scientific Practice
Background:
- Science generates novel theories and results rapidly.
- Simultaneously, significant issues in scientific practice lead to irreproducible and invalid reports.
- This creates a perceived paradox in scientific advancement.
Purpose of the Study:
- To analyze the paradox of rapid scientific progress alongside reproducibility challenges.
- To argue that this paradox is an intrinsic and historical aspect of science.
- To propose strategies for improving scientific practice without hindering progress.
Main Methods:
- Review of challenges impacting scientific success.
- Analysis of historical and current factors enabling scientific work.
- Discussion of selective remedies for scientific practice.
Main Results:
- The paradox is not new but a persistent feature of science.
- Numerous challenges can impede scientific success.
- Factors enabling science have evolved but remain crucial.
- Selective application of remedies is necessary to avoid slowing progress.
Conclusions:
- The apparent paradox is an inherent characteristic of the scientific process.
- Improvements in scientific practice should be selective to maintain progress.
- Communicating science must highlight both challenges and immense societal benefits.
Related Concept Videos
The Scientific Method
The Scientific Method
Generally, predictions are tested using carefully-designed experiments. Based on the outcome of these...
The Scientific Method
Scientific Laws and Theories
Scientific Nature of Social Psychology
The Scientific Method in Nursing Process
When using research findings to change practice, one must understand the process used to guide a study. The scientific method is a systematic, step-by-step process that supports the data's validity, reliability, and generalizability. As a result, findings can be...

