Related Experiment Video

Updated: Aug 9, 2026

Generation of Human Alloantigen-specific T Cells from Peripheral Blood
09:47

Generation of Human Alloantigen-specific T Cells from Peripheral Blood

Published on: November 21, 2014

Human T cell subsets

P C Beverley

    Immunology Letters
    |April 1, 1987
    PubMed

    Several monoclonal antibodies (mAbs) demonstrate further heterogeneity of CD4 and CD8. Within CD4, two major subsets can be identified with helper/inducer and suppressor/inducer functions. It is argued that suppressor/inducers, identified by CD45R mAbs, are immature or virgin T cells and therefore respond poorly to recall antigens. Helper/inducers are CD45R negative but express the UCHL1 antigen, which appears to be part of CD45. These cells respond well to recall antigens and are therefore mature or memory T cells. Several antigens not related to CD45, such as 4B4, Leu8, TQ1 and 9.3, identify functionally distinct subsets rather than stages of T cell maturation.

    More Related Videos

    Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets07:12

    Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets

    Published on: April 16, 2015

    Discrimination of Seven Immune Cell Subsets by Two-fluorochrome Flow Cytometry10:58

    Discrimination of Seven Immune Cell Subsets by Two-fluorochrome Flow Cytometry

    Published on: March 5, 2019

    Related Concept Videos

    Multipotency of Hematopoietic Stem Cells01:19

    Multipotency of Hematopoietic Stem Cells

    The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
    Cells of the Adaptive Immune Response01:23

    Cells of the Adaptive Immune Response

    The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
    Antigens Involved in Adaptive Immunity01:26

    Antigens Involved in Adaptive Immunity

    An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
    Complete Antigens
    Complete antigens possess both immunogenicity and reactivity.
    Diversity of Antigen Receptors01:28

    Diversity of Antigen Receptors

    Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
    Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
    T Cell Activation and Clonal Selection01:22

    T Cell Activation and Clonal Selection

    T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
    Naive T cells that have not yet encountered an antigen express two primary CD...
    T Cell Types and Functions01:24

    T Cell Types and Functions

    When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
    Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...