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meta-Directing Deactivators: –NO2, –CN, –CHO, –&NoBreak;CO2R, –COR, –CO2H

meta-Directing Deactivators: –NO₂, –CN, –CHO, –⁠CO₂R, –COR, –CO₂H

All meta-directing substituents are deactivating groups. These substituents withdraw electrons from the aromatic ring, making the ring less reactive toward electrophilic substitution. For example, the nitration of nitrobenzene is 100,000 times slower than that of benzene because of the deactivating effect of the nitro group. The first step in an electrophilic aromatic substitution is the addition of an electrophile to form a resonance-stabilized carbocation. The energy diagrams for...

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Related Experiment Video

Updated: Feb 13, 2026

Oscillation and Reaction Board Techniques for Estimating Inertial Properties of a Below-knee Prosthesis

Oscillation and Reaction Board Techniques for Estimating Inertial Properties of a Below-knee Prosthesis

Published on: May 8, 2014

Cor Triatriatum Sinistrum

Hitesh Raheja¹, Vinod Namana¹, Norbert Moskovits¹

¹Maimonides Medical Center, NY - USA.

Arquivos Brasileiros De Cardiologia

|March 15, 2018

Summary

No abstract available in PubMed .

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